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Maternal Diabetes, Related Biomarkers And Genes, And Risk Of Orofacial Clefts, Tiwaporn Maneerattanasuporn
Maternal Diabetes, Related Biomarkers And Genes, And Risk Of Orofacial Clefts, Tiwaporn Maneerattanasuporn
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Orofacial clefts (OFCs) are among the most common congenital birth defects and are characterized by incomplete development of the lip or the palate or both. The lip and palate develop separately at different times during the first trimester of pregnancy. The etiology of OFCs is multifactorial and includes a combination of genetic and environmental factors. This project aims to examine role of maternal diabetes mellitus in orofacial clefts through studies of medical histories, biomarkers, and genes.
In a study of Utah birth certificates, mothers with pre-existing diabetes and gestational diabetes mellitus (GDM) had an increased risk of OFCs, and obese …