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The Effect Of Oil Palm Phenolics (Opp) On Pancreatic Ductal Adenocarcinoma (Pdac) In Transgenic Mouse Model, Nurul Huda Razalli
The Effect Of Oil Palm Phenolics (Opp) On Pancreatic Ductal Adenocarcinoma (Pdac) In Transgenic Mouse Model, Nurul Huda Razalli
Wayne State University Dissertations
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive form of pancreatic cancer with low survival rates partly due to late diagnosis and poor treatment outcomes. The use of chemotherapy drug, gemcitabine alone often provides minimal benefits. This study explored the in vivo effect of oil palm phenolics (OPP), a water-soluble extract from oil palm in transgenic mouse model of PDAC and its combination with gemcitabine. Administration of 5% dietary OPP was found to be non-toxic in non-PDAC controls. Compared to single agent therapy with either OPP or gemcitabine, OPP-gemcitabine combination showed a superior benefit with profound synergistic effect both as …
The In Vivo Effect Of Oil Palm Phenolics (Opp) In Atherogenic Diet Induced Rats Model Of Alzheimer’S Disease (Ad), Yan Wu
Wayne State University Dissertations
Alzheimer’s disease (AD) is the most common cause of dementia in the aging population. It is characterized by cognitive decline and deposition of ß-amyloid plaques in the hippocampus. It has been shown that hypercholesterolemia induced by high cholesterol diet is associated with AD development. Increased level of oxidative stress has also been observed in AD patients. An important strategy to treat or delay the impairment is based on dietary modification, using food supplements. OPP, a water soluble fraction from oil palm fruit, rich in phenolics has been found to possess significant antioxidant activities. Its beneficial effects on cardiovascular diseases, diabetes …