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Nutrition And Genes Associated With Orofacial Cleft Birth Defects In Utah, Huong Dieu Meeks
Nutrition And Genes Associated With Orofacial Cleft Birth Defects In Utah, Huong Dieu Meeks
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Orofacial clefts (OFCs) are facial malformations that happen during early pregnancy and have a complex and heterogeneous etiology, involving both genetic and environmental risk factors. This project examined the association between maternal nutrition, folate-related biomarkers, candidate genes involved in one-carbon metabolism (OCM), and OFCs in order to achieve more comprehensive knowledge of how nutrition and genetics influence OFC risk. All studies performed in this project used the data collected in the Utah Child and Family Health Study (UCFHS) and the Johns Hopkins International Cleft Consortium.
Neither maternal periconceptional multivitamin use nor healthy dietary pattern score alone was individually associated with …