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Full-Text Articles in Life Sciences
Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis
Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis
Theses and Dissertations
The consolidation of fear memories is known to depend on a number of critical cellular processes including de novo protein synthesis and 26S proteasome-dependent protein degradation following auditory fear conditioning (Jarome et al., 2011; Kwapis et al., 2011). Early work has suggested that protein degradation, mediated by the ubiquitin proteasome system (UPS), may regulate the requirement for de novo protein synthesis during memory consolidation (Jarome & Helmstetter, 2014). However, the precise way in which the UPS is able to regulate mechanisms of protein synthesis remain unclear. In the present set of experiments, we investigated the role of the protein phosphatase …
Category-Specific Item Recognition And The Medial Temporal Lobe, Christopher B. Martin
Category-Specific Item Recognition And The Medial Temporal Lobe, Christopher B. Martin
Electronic Thesis and Dissertation Repository
Much neuropsychological and neuroimaging research has been focused on the contributions of different medial temporal lobe (MTL) structures to recognition memory. The majority of these studies have linked perirhinal cortex (PrC) to item recognition, whereas the hippocampus and parahippocampal cortex (PhC) have primarily been associated with the recollection of contextual detail pertaining to a specific prior stimulus encounter. Here, I report results from three fMRI studies that examined the neural correlates of item recognition with a specific focus on the relationship between such signals and category-specific effects in the MTL. In Chapter 2, I reveal that category-specific representations in both …
Effects Of 17Β-Estradiol On Learning And Memory And Strategy Use During A Hole Board Spatial Navigation Task In Aged Male Rats, Megan Berthiaume
Effects Of 17Β-Estradiol On Learning And Memory And Strategy Use During A Hole Board Spatial Navigation Task In Aged Male Rats, Megan Berthiaume
Seton Hall University Dissertations and Theses (ETDs)
Treatment with 17β- estradiol has been shown to ameliorate age related deficits in spatial learning and memory as well as to promote the use of an allocentric strategy during spatial navigation. While the majority of research using 17β- estradiol has been done using females rodents, there have been studies showing an improvement in spatial learning and memory and promoted use of allocentric strategies in spatial navigation in males as well. In males testosterone (T) is metabolized into estradiol by aromatase. As circulating levels of T decline with aging there is less available T to be metabolized into estradiol. The current …
Cortisol Levels And Voltage Conditions Of College Students, Adriana Steffens
Cortisol Levels And Voltage Conditions Of College Students, Adriana Steffens
Walden Dissertations and Doctoral Studies
There is a limited research base on low voltage brain conditions, which are characterized by electrical activity being measured at below 20 microvolts. The purpose of this study was to examine the relationship between saliva cortisol levels and voltage using an EGG in a college student population. Illuminating this relationship is important to inform how low voltage conditions can affect daily memory and cognitive functioning of undergraduate college students that may be a result of stress. The college student population may be vulnerable to the low voltage condition because of stress from the transition between teenage and adult life and …