Life Sciences Commons^™

Testing The Efficacy Of Lsn2463359, A Metabotropic Glutamate 5 Receptor Positive Allosteric Modulator, In Animal Models Of Schizophrenia, Dierdre M. Freamon

Seton Hall University Dissertations and Theses (ETDs)

For many years the dominant theory surrounding the cause of schizophrenia was focused on elevated dopamine levels found in critical areas of the brain. Recently a new theory has emerged pointing to elevated glutamate levels resulting from hypofunction of NMDA receptors and hypoactivity of GABAergic neurons which normally inhibit glutamatergic cells in a tonic manner. Therefore, while traditional antipsychotics directly block dopamine receptors, some of the newly generated compounds are designed to modulate glutamate to normal levels.

I propose testing the efficacy of the metabotropic glutamate 5 receptor modulator LSN2463359, previously shown to act as an indirect agonist of the …

The Effects Of Modafinil And Atomoxetine On Dopamine Signaling In The Striatal Subregions Of The Rat, Martin Bobak

Theses and Dissertations

In an effort to combat diseases and disorders that impede our health, comfort and well-being, an abundance of prescription drugs have emerged in the past 60 years. Many prescription drugs have remarkable efficacy for treating the primary symptoms of these diseases and disorders; however, some drugs carry negative side effects that impose their own adverse symptoms, albeit, often to a lesser degree than the primary symptoms. Thus, one of the main objectives of the pharmaceutical industry is to innovate and develop novel therapeutics, which remediate the primary symptoms of disease and lack undesirable negative side effects. However, in order to …

Electrical Stimulation Uses Sodium Channel Dependent Depolarization To Produce Exocytotic-Like Dopamine Release And Rotational Behavior In Vivo, Alice Elaine Hernandez

Open Access Theses & Dissertations

The goal of this project was to establish Electrical Stimulation (ES) in combination with In Vivo Intracerebral Microdialysis (IVMCD) as a methodology to evoke exocytotic-like dopamine (DA) release. To provide evidence that ES mimics action potential-mediated DA exocytosis, we hypothesized that ES produces depolarization of the membrane potential that is dependent upon sodium (Na+) -channels to produce DA release concomitantly with rotational behavior. To test this, rats received electrode and cannulae implants along the medial forebrain bundle, which contains the DAergic nigrostriatal pathway, and a microdialysis probe at the striatum to undergo IVMCD testing. To begin, steady baseline DA levels …

Dopamine Regulation Of Disengagement In The Basal Ganglia Circuitry, Mabel N. Terminel

Open Access Theses & Dissertations

Evidence suggests that dopamine (DA) is crucial for initiation and termination as well as sustained execution of movement. For the present study, it was hypothesized that DA plays a more important role in initiation and termination of movement than in its sustained production. To test these hypotheses, rats were trained to walk on a treadmill in a continuous and discontinuous (walk 30 secs/stop 15 seconds) fashion for one hour while striatal DA samples were collected using In Vivo Microdialysis (IVMCD). We predicted larger increases during discontinuous compared to continuous walking. It was found that brain dialysate levels of DA consistently …