Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Smith College (10)
- City University of New York (CUNY) (9)
- University of Nebraska - Lincoln (9)
- University of Connecticut (7)
- Belmont University (6)
-
- DePauw University (3)
- Florida International University (3)
- LSU Health Science Center (3)
- Hope College (2)
- Liberty University (2)
- Missouri University of Science and Technology (2)
- Technological University Dublin (2)
- University of Kentucky (2)
- University of Pennsylvania Carey Law School (2)
- Western Washington University (2)
- Aga Khan University (1)
- Antioch University (1)
- Case Western Reserve University (1)
- Connecticut College (1)
- Edith Cowan University (1)
- Florida Institute of Technology (1)
- Furman University (1)
- Gettysburg College (1)
- John Carroll University (1)
- Lindenwood University (1)
- Linfield University (1)
- Montclair State University (1)
- Northern Illinois University (1)
- Nova Southeastern University (1)
- Old Dominion University (1)
- Keyword
-
- Meta-analysis (4)
- Anxiety (3)
- Depression (3)
- FMRI (3)
- Neurodegeneration (3)
-
- Neuroimaging (3)
- Neuroscience (3)
- Stress (3)
- Tau (3)
- ADHD (2)
- Addiction (2)
- Alzheimer’s disease (2)
- Autism (2)
- Behavior (2)
- COVID-19 pandemic (2)
- Criminal law (2)
- Emotion (2)
- Hippocampus (2)
- Importin (2)
- Norepinephrine (2)
- Nucleocytoplasmic transport (2)
- Optic tectum (2)
- Prion disease (PrD) (2)
- Psychopathology (2)
- Tauopathies (2)
- Traumatic brain injury (2)
- Treatment (2)
- 5-HT 1A receptor (1)
- ABCD dataset (1)
- ADNI (1)
- Publication
-
- Neuroscience: Faculty Publications (10)
- Publications and Research (9)
- Center for Brain, Biology, and Behavior: Faculty and Staff Publications (8)
- Honors Scholar Theses (6)
- Belmont University Research Symposium (BURS) (4)
-
- FIU Electronic Theses and Dissertations (3)
- Faculty Scholarship (3)
- School of Medicine Faculty Publications (3)
- 21st Annual Celebration of Undergraduate Research and Creative Activity (2022) (2)
- All Faculty Scholarship (2)
- Annual Student Research Poster Session (2)
- Articles (2)
- WWU Honors College Senior Projects (2)
- 2022 Faculty Bibliography (1)
- Antioch University Dissertations & Theses (1)
- Behavioral Neuroscience Honors Papers (1)
- Biology Faculty Publications (1)
- Chemistry and Physics Faculty Articles (1)
- Civil, Architectural and Environmental Engineering Faculty Research & Creative Works (1)
- Department of Biology Faculty Scholarship and Creative Works (1)
- Faculty & Staff Publications (1)
- Faculty Peer-Reviewed Publications (1)
- Faculty Scholarship for the College of Science & Mathematics (1)
- Graduate Research Projects (1)
- Holster Scholar Projects (1)
- Honors Scholars Collaborative Projects (1)
- Honors Theses (1)
- Kinesiology Faculty Articles (1)
- Link Foundation Modeling, Simulation and Training Fellowship Reports (1)
- Masters Theses (1)
Articles 1 - 30 of 88
Full-Text Articles in Life Sciences
Input From Torus Longitudinalis Drives Binocularity And Spatial Summation In Zebrafish Optic Tectum, Alexander L. Tesmer, Nicholas P. Fields, Estuardo Robles
Input From Torus Longitudinalis Drives Binocularity And Spatial Summation In Zebrafish Optic Tectum, Alexander L. Tesmer, Nicholas P. Fields, Estuardo Robles
Neuroscience: Faculty Publications
Background: A continued effort in neuroscience aims to understand the way brain circuits consisting of diverse neuronal types generate complex behavior following sensory input. A common feature of vertebrate visual systems is that lower-order and higher-order visual areas are reciprocally connected. Feedforward projections confer visual responsiveness to higher-order visual neurons while feedback projections likely serve to modulate responses of lower-order visual neurons in a context-dependent manner. Optic tectum is the largest first-order visual brain area in zebrafish and is reciprocally connected with the torus longitudinalis (TL), a second-order visual brain area that does not receive retinal input. A functional role …
Rapamycin Inhibits Light-Induced Necrosome Activation Occurring In Wild-Type, But Not Rpe65-Null, Mouse Retina, Chunfeng Lu, Songhua Li, Minghao Jin
Rapamycin Inhibits Light-Induced Necrosome Activation Occurring In Wild-Type, But Not Rpe65-Null, Mouse Retina, Chunfeng Lu, Songhua Li, Minghao Jin
School of Medicine Faculty Publications
PURPOSE. Both photodamage and aberrant visual cycle contribute to disease progress of many retinal degenerative disorders, whereas the signaling pathways causing photoreceptor death remain unclear. Here we investigated the effects of intense photo-stress on (1) necrosome activation in wild-type and RPE65-null mice, (2) interaction of p62/Sequestosome-1 with the necrosome proteins, and (3) the effects of rapamycin on photodamage-induced necrosome activation and retinal degeneration in wild-type mice. METHODS. Dark-adapted rd12 mice and 129S2/Sv mice with or without rapamycin treatment were exposed to 15,000 lux light for different times. Expression levels and subcellular localization of proteins were determined through immunoblot and immunohistochemical …
Distinct Thalamic And Frontal Neuroanatomical Substrates In Children With Familial Vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (Adhd), Rahman Baboli, Meng Cao, Jeffrey M. Halperin, Xiaobo Li
Distinct Thalamic And Frontal Neuroanatomical Substrates In Children With Familial Vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (Adhd), Rahman Baboli, Meng Cao, Jeffrey M. Halperin, Xiaobo Li
Publications and Research
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent, inheritable, and heterogeneous neurodevelopmental disorder. Children with a family history of ADHD are at elevated risk of having ADHD and persisting its symptoms into adulthood. The objective of this study was to investigate the influence of having or not having positive family risk factor in the neuroanatomy of the brain in children with ADHD. Cortical thickness-, surface area-, and volume-based measures were extracted and compared in a total of 606 participants, including 132, 165, and 309 in groups of familial ADHD (ADHD-F), non-familial ADHD (ADHD-NF), and typically developed children, respectively. Compared to controls, …
Identification Of Clinical And Behavioral Outcomes Predictive Of Ftld-Tdp Pathology, Nevin Crow, Virginia A. Berry, Eric Febles
Identification Of Clinical And Behavioral Outcomes Predictive Of Ftld-Tdp Pathology, Nevin Crow, Virginia A. Berry, Eric Febles
Science University Research Symposium (SURS)
Frontotemporal Lobar Dementia (FTLD) is a neurogenerative disease often misdiagnosed as Alzheimer’s Disease (AD), resulting in poor treatment outcomes (Rascovsky et al., 2011). Multi-factorial approaches are increasingly being applied to yield more accurate and earlier diagnoses. These standard clinical outcomes include MRI imaging, biomarkers, and assessments of cognitive ability. While each of these outcomes are partially predictive of FTLD diagnosis, none alone carry enough power to differentiate FTLD patients from other dementias, including AD. One notable variable is TDP-43, a DNA-binding protein involved in regulating the FTLD risk gene UNC13A, suggested as one of the more effective biomarkers for early …
Maternal Mental Health Mediates The Effects Of Pandemic-Related Stressors On Adolescent Psychopathology During Covid-19, Liliana J. Lengua, Stephanie F. Thompson, Stephanie Gyuri Kim, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Maureen Zalewski, Andrew Meltzoff, Kate A. Mclaughlin
Maternal Mental Health Mediates The Effects Of Pandemic-Related Stressors On Adolescent Psychopathology During Covid-19, Liliana J. Lengua, Stephanie F. Thompson, Stephanie Gyuri Kim, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Maureen Zalewski, Andrew Meltzoff, Kate A. Mclaughlin
Neuroscience: Faculty Publications
Background: This study examined whether COVID-19-related maternal mental health changes contributed to changes in adolescent psychopathology. Methods: A community sample of 226 adolescents (12 years old before COVID-19) and their mothers were asked to complete COVID-19 surveys early in the pandemic (April–May 2020, adolescents 14 years) and approximately 6 months later (November 2020–January 2021). Surveys assessed pandemic-related stressors (health, financial, social, school, environment) and mental health. Results: Lower pre-pandemic family income-to-needs ratio was associated with higher pre-pandemic maternal mental health symptoms (anxiety, depression) and adolescent internalizing and externalizing problems, and with experiencing more pandemic-related stressors. Pandemic-related stressors predicted increases in …
Early-Childhood Temperament Moderates The Prospective Associations Of Coping With Adolescent Internalizing And Externalizing Symptoms, Michele R. Smith, Krystal H. Parrish, Lisa Shimomaeda, Maureen Zalewski, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Andrew N. Meltzoff, Katie A. Mclaughlin, Liliana J. Lengua
Early-Childhood Temperament Moderates The Prospective Associations Of Coping With Adolescent Internalizing And Externalizing Symptoms, Michele R. Smith, Krystal H. Parrish, Lisa Shimomaeda, Maureen Zalewski, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Andrew N. Meltzoff, Katie A. Mclaughlin, Liliana J. Lengua
Neuroscience: Faculty Publications
While appraisal and coping are known to impact adolescent psychopathology, more vulnerable or resilient responses to stress may depend on individual temperament. This study examined early life temperament as a moderator of the prospective relations of pre-adolescent appraisal and coping with adolescent psychopathology. The sample included 226 (62% female, 14–15 years) adolescents with assessments starting at 3 years of age. Adolescents were predominately White (12% Black 9% Asian, 11% Latinx, 4% Multiracial, and 65% White). Observed early-childhood temperament (fear, frustration, executive control, and delay ability) were tested as moderators of pre-adolescent coping (active and avoidant) and appraisal (threat, positive) on …
Females Exhibit Higher Glua2 Levels And Outperform Males In Active Place Avoidance Despite Increased Amyloid Plaques In Tgf344‑Alzheimer’S Rats, Osama Chaudry, Kelechi Ndukwe, Maria Figuiredo-Perira, Peter A. Serrano, Patricia Rockwell
Females Exhibit Higher Glua2 Levels And Outperform Males In Active Place Avoidance Despite Increased Amyloid Plaques In Tgf344‑Alzheimer’S Rats, Osama Chaudry, Kelechi Ndukwe, Maria Figuiredo-Perira, Peter A. Serrano, Patricia Rockwell
Publications and Research
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is most prevalent in females. While estrogen provides neuroprotection in females, sex mediated differences in the development of AD pathology are not fully elucidated. Therefore, comparing events between sexes in early-stage AD pathology may reveal more effective therapeutic targets of intervention. To address sex differences, we analyzed early-stage 9-month male and female TgF344-AD (Tg-AD) rats, an AD model carrying the APPswe and Presenilin 1 (PS1ΔE9) mutations that develops progressive age-dependent AD pathology similar to humans. Tg-AD females significantly outperformed Tg-AD males in the active place avoidance (aPAT) test that assesses hippocampal-dependent …
The Impact Of Covid-19 Pandemic On Undergraduate Students’ Interest In The Stem Field, Zaheen Rashed '24, Yuchen Jiang, Zimo Ma, Pamela Propsom
The Impact Of Covid-19 Pandemic On Undergraduate Students’ Interest In The Stem Field, Zaheen Rashed '24, Yuchen Jiang, Zimo Ma, Pamela Propsom
Annual Student Research Poster Session
The deadly consequences of COVID-19 have been well documented, as have the social, emotional, and cognitive effects. These sequelae extend to the educational system. Much less investigated have been the potential positive outcomes of the pandemic. Given that STEM education relies heavily on hands-on laboratory experiences, STEM students may have been especially impacted by pandemic-imposed remote instruction. We surveyed 392 students at one liberal arts college querying why they continue studying in STEM or leave the STEM disciplines. Because the literature indicates that people of color and those from lower socioeconomic groups were more negatively affected by COVID-19, we hypothesized …
Investigating Conflicts In Mind Wandering And Neural Oscillation Studies, Mahnoor Zahid, Robert West
Investigating Conflicts In Mind Wandering And Neural Oscillation Studies, Mahnoor Zahid, Robert West
Annual Student Research Poster Session
When presented with a repetitive or an undemanding task, our mind tends to disengage from the external environment to focus on the inner trains of thought. This phenomenon, commonly known as "zoning out" is termed as Mind Wandering. Across various literature', this effect has been mainly studied under two states: while performing a low-demand task, or under a meditative state. Neural oscillations such as alpha, beta, delta and theta waves were studied to observe varying effects of mind wandering and to distinguish how and when a human mind goes into this state. It was hypothesized that one wave would prove …
Exposure To Violence As An Environmental Pathway Linking Low Socioeconomic Status With Altered Neural Processing Of Threat And Adolescent Psychopathology, David G. Weissman, Maya L. Rosen, Natalie L. Colich, Kelly A. Sambrook, Liliana J. Lengua, Margaret A. Sheridan, Katie A. Mclaughlin
Exposure To Violence As An Environmental Pathway Linking Low Socioeconomic Status With Altered Neural Processing Of Threat And Adolescent Psychopathology, David G. Weissman, Maya L. Rosen, Natalie L. Colich, Kelly A. Sambrook, Liliana J. Lengua, Margaret A. Sheridan, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Low childhood socioeconomic status (SES) is associated with increased risk for psychopathology, in part because of heightened exposure to environmental adversity. Adverse experiences can be characterized along dimensions, including threat and deprivation, that contribute to psychopathology via distinct mechanisms. The current study investigated a neural mechanism through which threat and deprivation may contribute to socioeconomic disparities in psychopathology. Participants were 177 youths (83 girls) aged 10–13 years recruited from a cohort followed since the age of 3 years. SES was assessed using the income-to-needs ratio at the age of 3 years. At the age of 10–13 years, retrospective and current …
Alzheimer's Disease, Dylan L. Weber
Alzheimer's Disease, Dylan L. Weber
Student Publications
An overview of the background, etiology, pathophysiology, clinical features, diagnosis, treatment and prevention of Alzheimer's disease.
The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.
The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.
Faculty Scholarship
We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and age-related diseases which contribute to increased morbidity with age. Geriatric populations are rarely considered in the development of environmental regulations or in toxicology research. Today, life expectancy is often into one’s 80s or beyond, which means multiple decades living as a geriatric individual. Hence, adverse health effects and late-onset diseases might be due to environmental exposures as a geriatric, and we currently have no way of …
Roundup And Glyphosate’S Impact On Gaba To Elicit Extended Proconvulsant Behavior In Caenorhabditis Elegans, Akshay Naraine, Rebecca Aker, Isis Sweeney, Meghan Kalvey, Alexis Surtel, Venkatesh Shanbhag, Ken Dawson-Scully
Roundup And Glyphosate’S Impact On Gaba To Elicit Extended Proconvulsant Behavior In Caenorhabditis Elegans, Akshay Naraine, Rebecca Aker, Isis Sweeney, Meghan Kalvey, Alexis Surtel, Venkatesh Shanbhag, Ken Dawson-Scully
Chemistry and Physics Faculty Articles
As 3 billion pounds of herbicides are sprayed over farmlands every year, it is essential to advance our understanding how pesticides may influence neurological health and physiology of both humans and other animals. Studies are often one-dimensional as the majority examine glyphosate by itself. Farmers and the public use commercial products, like Roundup, containing a myriad of chemicals in addition to glyphosate. Currently, there are no neurological targets proposed for glyphosate and little comparison to Roundup. To investigate this, we compared how glyphosate and Roundup affect convulsant behavior in C. elegans and found that glyphosate and Roundup increased seizure-like behavior. …
Explicit And Implicit Emotion Processing In The Cerebellum: A Meta‑Analysis And Systematic Review, Jordan E. Pierce, Marine Thomasson, Philippe Voruz, Garance Selosse, Julie Péron
Explicit And Implicit Emotion Processing In The Cerebellum: A Meta‑Analysis And Systematic Review, Jordan E. Pierce, Marine Thomasson, Philippe Voruz, Garance Selosse, Julie Péron
Center for Brain, Biology, and Behavior: Faculty and Staff Publications
The cerebellum’s role in affective processing is increasingly recognized in the literature, but remains poorly understood, despite abundant clinical evidence for affective disruptions following cerebellar damage. To improve the characterization of emotion processing and investigate how attention allocation impacts this processing, we conducted a meta-analysis on task activation foci using GingerALE software. Eighty human neuroimaging studies of emotion including 2761 participants identified through Web of Science and ProQuest databases were analyzed collectively and then divided into two categories based on the focus of attention during the task: explicit or implicit emotion processing. The results examining the explicit emotion tasks identified …
Axonal Architecture Of The Mouse Inner Retina Revealed By Second Harmonic Generation, Arafat Meah, Vinessia Boodram, Festa Bucinca-Cupallari, Hyungsik Lim
Axonal Architecture Of The Mouse Inner Retina Revealed By Second Harmonic Generation, Arafat Meah, Vinessia Boodram, Festa Bucinca-Cupallari, Hyungsik Lim
Publications and Research
We describe a novel method for visualizing the network of axons in the unlabeled fresh wholemount retina. The intrinsic radiation of second harmonic generation (SHG) was utilized to visualize single axons of all major retinal neurons, i.e., photoreceptors, horizontal cells, bipolar cells, amacrine cells, and the retinal ganglion cells. The cell types of SHG + axons were determined using transgenic GFP/YFP mice. New findings were obtained with retinal SHG imaging: Müller cells do not maintain uniformly polarized microtubules in the processes; SHG + axons of bipolar cells terminate in the inner plexiform layer (IPL) in a subtype-specific manner; a subset …
Using Event-Related Brain Potentials To Explore The Temporal Dynamics Of Decision-Making Related To Information Security, Robert West, Bridget Kirby, Kaitlyn Malley
Using Event-Related Brain Potentials To Explore The Temporal Dynamics Of Decision-Making Related To Information Security, Robert West, Bridget Kirby, Kaitlyn Malley
Psychology and Neuroscience Faculty Publications
Insider threat from individuals operating within an organization presents a significant source of violations of information security. Our previous research has used scalp recorded event-related brain potentials (ERPs) and the Information Security Paradigm (ISP) to identify the neural correlates of decision-making processes related to violations of information security. In the current study, we sought to expand this research by examining the effects of two variables that were drawn from the broader decision-making literature (i.e., the benefactor and delay of a reward) on ERPs measured in the ISP. In the ISP we varied whether Josh—a hypothetical IT specialist—or a significant other …
Mechanisms Of Motor Learning In Lmmersive Virtual Reality And Their Influences On Retention And Context Transfer, Julia M. Juliano
Mechanisms Of Motor Learning In Lmmersive Virtual Reality And Their Influences On Retention And Context Transfer, Julia M. Juliano
Link Foundation Modeling, Simulation and Training Fellowship Reports
lmmersive virtual reality using a head-mounted display (HMD-VR) is increasingly being used for motor learning purposes. These devices have the potential to be useful tools in motor training and rehabilitation as they allow for researchers and clinicians to control and individualize the virtual environment. However, we do not yet know how to maximize these devices potential because the mechanisms underlying how we move and learn motor skills in them are unclear. The central objective of my research is to address gaps in our understanding of what makes movements and motor learning in HMD-VR different from more conventional training environments and …
A Genetic Labeling System To Study Dendritic Spine Development In Zebrafish Models Of Neurodevelopmental Disorders, Elisabeth C. Demarco, George R. Stoner, Estuardo Robles
A Genetic Labeling System To Study Dendritic Spine Development In Zebrafish Models Of Neurodevelopmental Disorders, Elisabeth C. Demarco, George R. Stoner, Estuardo Robles
Neuroscience: Faculty Publications
Dendritic spines are the principal site of excitatory synapse formation in the human brain. Several neurodevelopmental disorders cause spines to develop abnormally, resulting in altered spine number and morphology. Although spine development has been thoroughly characterized in the mammalian brain, spines are not unique to mammals. We have developed a genetic system in zebrafish to enable high-resolution in vivo imaging of spine dynamics during larval development. Although spiny neurons are rare in the larval zebrafish, pyramidal neurons (PyrNs) of the zebrafish tectum form an apical dendrite containing a dense array of dendritic spines. To characterize dendritic spine development, we performed …
Assessing The Degree Of Ecological Validity Of Your Study: Introducing The Multidimensional Assessment Of Research In Context (Marc) Tool, Sandra Naumann, Michelle L. Byrne, Alethia De La Fuente, Anita Harrewijn, Tehila Nugiel, Maya Rosen, Nienke Van Atteveldt, Pawel J. Matusz
Assessing The Degree Of Ecological Validity Of Your Study: Introducing The Multidimensional Assessment Of Research In Context (Marc) Tool, Sandra Naumann, Michelle L. Byrne, Alethia De La Fuente, Anita Harrewijn, Tehila Nugiel, Maya Rosen, Nienke Van Atteveldt, Pawel J. Matusz
Neuroscience: Faculty Publications
In cognitive neurosciences, fundamental principles of mental processes and functional brain organization have been established with highly controlled tasks and testing environments. Recent technical advances allowed the investigation of these functions and their brain mechanisms in naturalistic settings. The diversity in those approaches have been recently (Matusz, P. J., Dikker, S., Huth, A. G., & Perrodin, C. (2019). Are we ready for real-world neuroscience? Journal of Cognitive Neuroscience, 31(3), 327–338. doi:10.1162/jocn_e_01276) classified via a three-category cycle, including controlled laboratory, partially naturalistic laboratory, and naturalistic real-world research. Based on this model, we developed the Multidimensional Assessment of Research in Context (MARC) …
Potential Psychoactive Effects Of Microalgal Bioactive Compounds For The Case Of Sleep And Mood Regulation: Opportunities And Challenges, Bozena Mccarthy, Graham O’Neill Dr, Nissreen Abu-Ghannam Prof.
Potential Psychoactive Effects Of Microalgal Bioactive Compounds For The Case Of Sleep And Mood Regulation: Opportunities And Challenges, Bozena Mccarthy, Graham O’Neill Dr, Nissreen Abu-Ghannam Prof.
Articles
Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review …
The Ubiquitin Ligase Siah2 Is A Female-Specific Regulator Of Circadian Rhythms And Metabolism, Tsedey Mekbib, Ting Chung Suen, Aisha Rollins-Hairston, Kiandra Smith, Ariel Armstrong, Cloe Gray, Sharon Owino, Kenkichi Baba, Julie E. Baggs, J. Christopher Ehlen, Gianluca Tosini, Jason P. Debruyne
The Ubiquitin Ligase Siah2 Is A Female-Specific Regulator Of Circadian Rhythms And Metabolism, Tsedey Mekbib, Ting Chung Suen, Aisha Rollins-Hairston, Kiandra Smith, Ariel Armstrong, Cloe Gray, Sharon Owino, Kenkichi Baba, Julie E. Baggs, J. Christopher Ehlen, Gianluca Tosini, Jason P. Debruyne
Neuroscience: Faculty Publications
Circadian clocks enable organisms to predict and align their behaviors and physiologies to constant daily day-night environmental cycle. Because the ubiquitin ligase Siah2 has been identified as a potential regulator of circadian clock function in cultured cells, we have used SIAH2-deficient mice to examine its function in vivo. Our experiments demonstrate a striking and unexpected sexually dimorphic effect of SIAH2-deficiency on the regulation of rhythmically expressed genes in the liver. The absence of SIAH2 in females, but not in males, altered the expression of core circadian clock genes and drastically remodeled the rhythmic transcriptome in the liver by increasing the …
Stress-Related Psychopathology During The Covid-19 Pandemic, Katie A. Mclaughlin, Maya L. Rosen, Steven W. Kasparek, Alexandra M. Rodman
Stress-Related Psychopathology During The Covid-19 Pandemic, Katie A. Mclaughlin, Maya L. Rosen, Steven W. Kasparek, Alexandra M. Rodman
Neuroscience: Faculty Publications
The COVID-19 pandemic has introduced widespread societal changes that have required ongoing adaptation. Unsurprisingly, stress-related psychopathology has increased during the pandemic, in both children and adults. We review these patterns through the lens of several leading conceptual models of the link between stress and psychopathology. Some of these models focus on characteristics of environmental stressors—including cumulative risk, specific stressor types, and stress sensitization approaches. Understanding the specific aspects of environmental stressors that are most likely to lead to psychopathology can shed light on who may be in most need of clinical intervention. Other models center on factors that can buffer …
Social Virtual Reality: Neurodivergence And Inclusivity In The Metaverse, James Hutson
Social Virtual Reality: Neurodivergence And Inclusivity In The Metaverse, James Hutson
Faculty Scholarship
Whereas traditional teaching environments encourage lively and engaged interaction and reward extrovert qualities, introverts, and others with symptoms that make social engagement difficult, such as autism spectrum disorder (ASD), are often disadvantaged. This population is often more engaged in quieter, low-key learning environments and often does not speak up and answer questions in traditional lecture-style classes. These individuals are often passed over in school and later in their careers for not speaking up and are assumed to not be as competent as their gregarious and outgoing colleagues. With the rise of the metaverse and democratization of virtual reality (VR) technology, …
Bakner And Coste Faculty-Student Summer Collaborative Research Grant: Grant Activities Evaluation Post Grant, Sarah Coste
Bakner And Coste Faculty-Student Summer Collaborative Research Grant: Grant Activities Evaluation Post Grant, Sarah Coste
Faculty & Staff Publications
Concise Abstract of the Results of the Work. Our research attempted to understand mechanisms underlying alcohol use and factors that may contribute to alcohol use disorder (AUD). More specifically, the present series of experiments, phases 1 through 4, expand on rodent models research to study binge-like ethanol consumption using the “Drinking In the Dark” (DID) procedure (see Thiele &Navarro, 2014 for a review). In DID, ethanol (EtOH) is provided in the home cage for 3 hours, beginning 3 hours after the start of the dark phase of the light:dark cycle when nocturnal rodents are most active (adapted from Rhodes et …
Developing And Validating Open Source Tools For Advanced Neuroimaging Research, Taylor Salo
Developing And Validating Open Source Tools For Advanced Neuroimaging Research, Taylor Salo
FIU Electronic Theses and Dissertations
Almost all scientific research relies on software. This is particularly true for research that uses neuroimaging technologies, such as functional magnetic resonance imaging (fMRI). These technologies generate massive amounts of data per participant, which must be processed and analyzed using specialized software. A large portion of these tools are developed by teams of researchers, rather than trained software developers. In this kind of ecosystem, where the majority of software creators are scientists, rather than trained programmers, it becomes more important than ever to rely on community-based development, which may explain why most of this software is open source. It is …
Norepinephrine Regulation Of Spatial Memory Using The Barnes Maze In Male And Female Rats, Serena Simpson, Ali Gheidi Phd, Nareen Sadik, Cameron J. Davidson Phd, Shane A. Perrine Phd
Norepinephrine Regulation Of Spatial Memory Using The Barnes Maze In Male And Female Rats, Serena Simpson, Ali Gheidi Phd, Nareen Sadik, Cameron J. Davidson Phd, Shane A. Perrine Phd
Medical Student Research Symposium
The role of norepinephrine (NE) in learning and memory has been extensively studied, yet its contribution remains to be clarified. This study aimed to investigate the role of NE on spatial learning and memory in female and male rats using a Barnes maze assay. We used N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), a specific noradrenergic neurotoxin that can cross the blood brain barrier, to deplete NE stores. We hypothesized that brain NE ablation would attenuate spatial learning and memory in rats. Loss of NE by DSP-4 was determined by measuring NE (and dopamine and serotonin) levels in several brain regions using HPLC. For the …
Mpc-Stanet: Alzheimer’S Disease Recognition Method Based On Multiple Phantom Convolution And Spatial Transformation Attention Mechanism, Yujian Liu, Kun Tang, Weiwei Cai, Aibin Chen, Guoxiong Zhou, Liujun Li, Runmin Liu
Mpc-Stanet: Alzheimer’S Disease Recognition Method Based On Multiple Phantom Convolution And Spatial Transformation Attention Mechanism, Yujian Liu, Kun Tang, Weiwei Cai, Aibin Chen, Guoxiong Zhou, Liujun Li, Runmin Liu
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Alzheimer's disease (AD) is a progressive neurodegenerative disease with insidious and irreversible onset. The recognition of the disease stage of AD and the administration of effective interventional treatment are important to slow down and control the progression of the disease. However, due to the unbalanced distribution of the acquired data volume, the problem that the features change inconspicuously in different disease stages of AD, and the scattered and narrow areas of the feature areas (hippocampal region, medial temporal lobe, etc.), the effective recognition of AD remains a critical unmet need. Therefore, we first employ class-balancing operation using data expansion and …
Respiratory Morbidity And Neurodevelopmental Outcomes In Infants Born Preterm: A Complex Web, Anna Maria Hibbs
Respiratory Morbidity And Neurodevelopmental Outcomes In Infants Born Preterm: A Complex Web, Anna Maria Hibbs
Faculty Scholarship
This commentary is on the original article by Yu et al. on pages 1246–1253 of this issue.
The Effects Of Floral Attributes And Conspecifics On Bumble Bee Forager Memory, Lucas Lauter, Tiffany Dinh
The Effects Of Floral Attributes And Conspecifics On Bumble Bee Forager Memory, Lucas Lauter, Tiffany Dinh
Undergraduate Research Symposium
What do bees remember about flowers? These memories are important for both bees and flowers. The bees have better foraging success and gain more nectar and pollen from flowers when they remember the most rewarding flower types. More memorable flowers will be visited more frequently, resulting in more successful pollination for the plant. At the same time, bees can also learn about flowers from other bees and may remember this information differently. We are training and testing three floral cues and a single social cue to see how the different types of cues affect their learning and memory of rewarding …
Age-Dependent White Matter Disruptions After Military Traumatic Brain Injury: Multivariate Analysis Results From Enigma Brain Injury, Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. Mcallister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey
Age-Dependent White Matter Disruptions After Military Traumatic Brain Injury: Multivariate Analysis Results From Enigma Brain Injury, Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. Mcallister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey
Center for Brain, Biology, and Behavior: Faculty and Staff Publications
Mild Traumatic brain injury (mTBI) is a signature wound in military personnel, and repetitive mTBI has been linked to age-related neurogenerative disorders that affect white matter (WM) in the brain. However, findings of injury to specific WM tracts have been variable and inconsistent. This may be due to the heterogeneity of mechanisms, etiology, and comorbid disorders related to mTBI. Non-negative matrix factorization (NMF) is a data-driven approach that detects covarying patterns (components) within high-dimensional data. We applied NMF to diffusion imaging data from military Veterans with and without a self-reported TBI history. NMF identified 12 independent components derived from fractional …