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Articles 1 - 26 of 26
Full-Text Articles in Life Sciences
Exploring Implications Of Synesthesia On Memory, Emily Brown
Exploring Implications Of Synesthesia On Memory, Emily Brown
Honors College Theses
This research proposal describes an original research procedure to study the effects of the neurological phenomenon of synesthesia (union of the senses) on memory. It provides supporting evidence as to how and why the proposed research fits into contemporary questions in the study of synesthesia.
Human Mst But Not Mt Responds To Tactile Stimulation, Michael S. Beauchamp, Nafi E. Yasar, Neel Kishan, Tony Ro
Human Mst But Not Mt Responds To Tactile Stimulation, Michael S. Beauchamp, Nafi E. Yasar, Neel Kishan, Tony Ro
Publications and Research
Previous reports of tactile responses in human visual area MT/V5 have used complex stimuli, such as a brush stroking the arm. These complex moving stimuli are likely to induce imagery of visual motion, which is known to be a powerful activator of MT. The area described as “MT” in previous reports consists of at least two distinct cortical areas, MT and MST. Using functional magnetic resonance imaging, we separately localized human MT and MST and measured their response to vibrotactile stimuli unlikely to induce imagery of visual motion. Strong vibrotactile responses were observed in MST but not in MT. Vibrotactile …
Social Control Of Brain Morphology In A Eusocial Mammal, Melissa M. Holmes, Greta J. Rosen, Cynthia L. Jordan, Geert De Vries, Bruce D. Goldman
Social Control Of Brain Morphology In A Eusocial Mammal, Melissa M. Holmes, Greta J. Rosen, Cynthia L. Jordan, Geert De Vries, Bruce D. Goldman
Neuroscience Institute Faculty Publications
Social status impacts reproductive behavior in diverse vertebrate species, but little is known about how it affects brain morphology. We explore this in the naked mole-rat, a species with the most rigidly organized reproductive hierarchy among mammals. Naked mole-rats live in large, subterranean colonies where breeding is restricted to a single female and small number of males. All other members of the colony, known as subordinates, are reproductively suppressed. Subordinates can become breeders if removed from the colony and placed with an opposite sex partner, but in nature most individuals never attain reproductive status. We examined the brains of breeding …
Brainstem Cholinergic Modulation Of Muscle Tone In Infant Rats, Andrew J. Gall, Amy Poremba, Mark S. Blumberg
Brainstem Cholinergic Modulation Of Muscle Tone In Infant Rats, Andrew J. Gall, Amy Poremba, Mark S. Blumberg
Faculty Publications
In week-old rats, lesions of the dorsolateral pontine tegmentum (DLPT) and nucleus pontis oralis (PnO) have opposing effects on nuchal muscle tone. Specifically, pups with DLPT lesions exhibit prolonged bouts of nuchal muscle atonia (indicative of sleep) and pups with PnO lesions exhibit prolonged bouts of high nuchal muscle tone (indicative of wakefulness). Here we test the hypothesis that nuchal muscle tone is modulated, at least in part, by cholinergically mediated interactions between these two regions. First, in unanesthetized pups, we found that chemical infusion of the cholinergic agonist carbachol (22 mM, 0.1 µL) within the DLPT produced high muscle …
Detecting Agency From The Biological Motion Of Veridical Vs Animated Agents, Raymond A. Mar, William M. Kelley, Todd F. Heatherton, C. Neil Macrae
Detecting Agency From The Biological Motion Of Veridical Vs Animated Agents, Raymond A. Mar, William M. Kelley, Todd F. Heatherton, C. Neil Macrae
Dartmouth Scholarship
The ability to detect agency is fundamental for understanding the social world. Underlying this capacity are neural circuits that respond to patterns of intentional biological motion in the superior temporal sulcus and temporoparietal junction. Here we show that the brain's blood oxygenation level dependent (BOLD) response to such motion is modulated by the representation of the actor. Dynamic social interactions were portrayed by either live-action agents or computer-animated agents, enacting the exact same patterns of biological motion. Using an event-related design, we found that the BOLD response associated with the perception and interpretation of agency was greater when identical physical …
Sensory Deprivation Alters Aggrecan And Perineuronal Net Expression In The Mouse Barrel Cortex, Paulette A. Mccrae, Mary M. Rocco, Gail Kelly, Joshua C. Brumberg, Russell T. Matthews
Sensory Deprivation Alters Aggrecan And Perineuronal Net Expression In The Mouse Barrel Cortex, Paulette A. Mccrae, Mary M. Rocco, Gail Kelly, Joshua C. Brumberg, Russell T. Matthews
Publications and Research
An important role for the neural extracellular matrix in modulating cortical activity-dependent synaptic plasticity has been established by a number of recent studies. However, identification of the critical molecular components of the neural matrix that mediate these processes is far from complete. Of particular interest is the perineuronal net (PN), an extracellular matrix component found surrounding the cell body and proximal neurites of a subset of neurons. Because of the apposition of thePNto synapses and expression of this structure coincident with the close of the critical period, it has been hypothesized that nets could play uniquely important roles in synapse …
Functional Dissociation In Frontal And Striatal Areas For Processing Of Positive And Negative Reward Information, Xun Liu, David K. Powell, Hongbin Wang, Brian T. Gold, Christine R. Corbly, Jane E. Joseph
Functional Dissociation In Frontal And Striatal Areas For Processing Of Positive And Negative Reward Information, Xun Liu, David K. Powell, Hongbin Wang, Brian T. Gold, Christine R. Corbly, Jane E. Joseph
Neuroscience Faculty Publications
Reward-seeking behavior depends critically on processing of positive and negative information at various stages such as reward anticipation, outcome monitoring, and choice evaluation. Behavioral and neuropsychological evidence suggests that processing of positive (e.g., gain) and negative (e.g., loss) reward information may be dissociable and individually disrupted. However, it remains uncertain whether different stages of reward processing share certain neural circuitry in frontal and striatal areas, and whether distinct but interactive systems in these areas are recruited for positive and negative reward processing. To explore these issues, we used a monetary decision-making task to investigate the roles of frontal and striatal …
Divisions Within The Posterior Parietal Cortex Help Touch Meet Vision, Catherine L. Reed
Divisions Within The Posterior Parietal Cortex Help Touch Meet Vision, Catherine L. Reed
CMC Faculty Publications and Research
The parietal cortex is divided into two major functional regions: the anterior parietal cortex that includes primary somatosensory cortex, and the posterior parietal cortex (PPC) that includes the rest of the parietal lobe. The PPC contains multiple representations of space. In Dijkerman and de Haan’s (see record 2007-13802-022) model, higher spatial representations are separate from PPC functions. This model should be developed further so that the functions of the somatosensory system are integrated with specific functions within the PPC and higher spatial representations. Through this further specification of the model, one can make better predictions regarding functional interactions between somatosensory …
Smoking During Pregnancy Affects Speech-Processing Ability In Newborn Infants, Alexandra P.F. Key, Melissa Ferguson, Dennis L. Molfese, Kelley Peach, Victoria J. Molfese
Smoking During Pregnancy Affects Speech-Processing Ability In Newborn Infants, Alexandra P.F. Key, Melissa Ferguson, Dennis L. Molfese, Kelley Peach, Victoria J. Molfese
Center for Brain, Biology, and Behavior: Faculty and Staff Publications
BACKGROUND: Tobacco smoking during pregnancy is known to adversely affect development of the central nervous system in babies of smoking mothers by restricting utero–placental blood flow and the amount of oxygen available to the fetus. Behavioral data associate maternal smoking with lower verbal scores and poorer performance on specific language/auditory tests.
OBJECTIVES: In the current study we examined the effects of maternal smoking during pregnancy on newborns’ speech processing ability as measured by event-related potentials (ERPs).
METHOD: High-density ERPs were recorded within 48 hr of birth in healthy newborn infants of smoking (n = 8) and nonsmoking …
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert Struble
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert Struble
Faculty Research & Creative Activity
Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possible sources of apoE in the olfactory epithelium (OE). Immunoblotting results revealed apoE expression in the OE of wild-type (WT) mice, but not in apoE deficient/knockout (KO) mice. Immunohistochemical studies revealed that the perikarya and processes of sustentacular (Sus) cells expressed apoE-like immunoreactivity. Minimal neuronal apoE immunostaining was seen, although apoE was observed in the …
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto P. Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert G. Struble
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto P. Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert G. Struble
Faculty Research & Creative Activity
Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possible sources of apoE in the olfactory epithelium (OE). Immunoblotting results revealed apoE expression in the OE of wild-type (WT) mice, but not in apoE deficient/knockout (KO) mice. Immunohistochemical studies revealed that the perikarya and processes of sustentacular (Sus) cells expressed apoE-like immunoreactivity. Minimal neuronal apoE immunostaining was seen, although apoE was observed in the …
Stroke Caregiving: Two Sides To The Story, Teresa Thompson
Stroke Caregiving: Two Sides To The Story, Teresa Thompson
Communication Faculty Publications
No abstract provided.
Cognitive And Affective Aspects Of Thigmotaxis Strategy In Humans, Janos Kallai, Tamas Makany, Arpad Csatho, Kazmer Karadi, David Horvath, Beatrix Kovacs-Labadi, Robert Jarai, Lynn Nadel, Jake W. Jacobs
Cognitive And Affective Aspects Of Thigmotaxis Strategy In Humans, Janos Kallai, Tamas Makany, Arpad Csatho, Kazmer Karadi, David Horvath, Beatrix Kovacs-Labadi, Robert Jarai, Lynn Nadel, Jake W. Jacobs
Research Collection Lee Kong Chian School Of Business
The present article describes the cognitive and emotional aspects of human thiginotaxis (a wall-following spatial strategy) during exploration of virtual and physical spaces. The authors assessed 106 participants with spatial and nonspatial performance-based learning-memory tasks and with fear and anxiety questionnaires. The results demonstrate that thiginotaxis plays a distinct role at different phases of spatial learning. The 1st phase shows a positive correlation between thigmotaxis and general phobic avoidance, whereas there is no association between thigmotaxis and general phobic avoidance during later phases of learning. Furthermore, participants who underperformed in working memory tests and in a spatial construction task exhibited …
Maintenance Of Visual Stability In The Human Posterior Parietal Cortex, Erik Chang, Tony Ro
Maintenance Of Visual Stability In The Human Posterior Parietal Cortex, Erik Chang, Tony Ro
Publications and Research
Visual stability refers to our stable visuospatial perceptions despite the unstable visual input caused by saccades. Functional neuroimaging results, studies on patients with posterior parietal cortex (PPC) lesions, and single-unit recordings in the lateral intraparietal sulcus of primates indirectly suggest that the PPC might be a potential locus of visual stability through its involvement with spatial remapping. Here we directly explored the role of the PPC in visual stability by applying transcranial magnetic stimulation (TMS) while participants performed a perisaccadic displacement detection task. We show that TMS over the PPC but not a frontal control site alters sensitivity to displacement …
Intermolecular Interactions Of Homologs Of Germ Plasm Components In Mammalian Germ Cells, Mark S. Fox, Amander T. Clark, Mohammed El Majdoubi, Jean-Louis Vigne, Jun Urano, Chris E. Hostetler, Michael D. Griswold, Richard I. Weiner, Renee A. Reijo Pera
Intermolecular Interactions Of Homologs Of Germ Plasm Components In Mammalian Germ Cells, Mark S. Fox, Amander T. Clark, Mohammed El Majdoubi, Jean-Louis Vigne, Jun Urano, Chris E. Hostetler, Michael D. Griswold, Richard I. Weiner, Renee A. Reijo Pera
Collected Faculty and Staff Scholarship
In some species such as flies, worms, frogs, and fish the key to forming and maintaining early germ cell populations is the assembly of germ plasm, croscopically-distinct egg cytoplasm that is rich in RNAs, RNA-binding proteins and ribosomes. Cells which inherit germ plasm are destined for the germ cell lineage. In contrast, in mammals, germ cells are formed and maintained later in development as a result of inductive signaling from one embryonic cell type to another. Research advances, using complementary approaches, including identification of key signaling factors that act during the initial stages of germ cell development, differentiation of germ …
Strokes Of Existence: The Connection Of All Things, Mari Gorman
Strokes Of Existence: The Connection Of All Things, Mari Gorman
Graduate Student Publications and Research
Acted or real—and all life is real whether one is acting or not—the common denominator and consistent, ubiquitous reality of life and all behavior is that it manifests in the form of relationships on all scales. But what is a relationship? Until now, the answer to this question has not been sufficiently known. As a result of many years of empirical research that began with the aim of discovering what is going on in a gifted actor when s/he is playing a character that can be observed and experienced as a living, intuitive being, and based on the knowledge that …
Effects Of Insular Cortex Lesions On Conditioned Taste Aversion And Latent Inhibition In The Rat, Christopher T. Roman, Steve Reilly
Effects Of Insular Cortex Lesions On Conditioned Taste Aversion And Latent Inhibition In The Rat, Christopher T. Roman, Steve Reilly
Scholarship and Professional Work – COPHS
The present study tested the hypothesis that lesions of the insular cortex of the rat retard the acquisition of conditioned taste aversions (CTAs) because of an impairment in the detection of the novelty of taste stimuli. Demonstrating the expected latent inhibition effect, nonlesioned control subjects acquired CTAs more rapidly when the conditioned stimulus (0.15% sodium saccharin) was novel rather than familiar (achieved by pre-exposure to the to-be-conditioned taste cue). However, rats with insular cortex lesions acquired taste aversions at the same slow rate regardless of whether the saccharin was novel or familiar. The pattern of behavioural deficits obtained cannot be …
Sex Differences In The Onset Of Seasonal Reproductive Quiescence In Hamsters, Annaliese K. Beery, Justin J. Trumbull, Jyeming M. Tsao, Ruth M. Costantini, Irving Zucker
Sex Differences In The Onset Of Seasonal Reproductive Quiescence In Hamsters, Annaliese K. Beery, Justin J. Trumbull, Jyeming M. Tsao, Ruth M. Costantini, Irving Zucker
Neuroscience: Faculty Publications
Day length is the primary cue used by many mammals to restrict reproduction to favourable spring and summer months, but it is unknown for any mammal whether the seasonal loss of fertility begins at the same time and occurs at the same rate in females and males; nor it established whether the termination of mating behaviour in males and females coincides with the loss of fertility. We speculated that females, owing to their greater energetic investment in reproduction, are the limiting sex in terminating offspring production in short days (SDs). Oestrous cycles and production of young were monitored in Syrian …
Female Rats Are More Vulnerable To The Long-Term Consequences Of Neonatal Inflammatory Injury, Jamie L. Laprairie, Anne Z. Murphy Phd
Female Rats Are More Vulnerable To The Long-Term Consequences Of Neonatal Inflammatory Injury, Jamie L. Laprairie, Anne Z. Murphy Phd
Neuroscience Institute Faculty Publications
Premature infants are routinely exposed to invasive medical procedures during neonatal intensive care treatment that are largely performed in the absence of anesthetics or analgesics. Data collected to date suggest that exposure to early insult during this time of increased plasticity alters the development of the CNS and influences future pain responses. As previous studies examining the impact of neonatal injury on nociception have been conducted primarily in males, the potential adverse effects on females are not known. Therefore, the present studies were conducted to determine whether neonatal injury differentially impacts male and female sensory thresholds in adulthood. A short …
Morphine Preferentially Activates The Periaqueductal Gray – Rostral Ventromedial Medullary Pathway In The Male Rat: A Potential Mechanism For Sex Differences In Antinociception, Dayna R. Loyd, Michael M. Morgan, Anne Z. Murphy Phd
Morphine Preferentially Activates The Periaqueductal Gray – Rostral Ventromedial Medullary Pathway In The Male Rat: A Potential Mechanism For Sex Differences In Antinociception, Dayna R. Loyd, Michael M. Morgan, Anne Z. Murphy Phd
Neuroscience Institute Faculty Publications
The midbrain periaqueductal gray (PAG), and its descending projections to the rostral ventromedial medulla (RVM), provide an essential neural circuit for opioid-produced antinociception. Recent anatomical studies have reported that the projections from the PAG to the RVM are sexually dimorphic and that systemic administration of morphine significantly suppresses pain-induced activation of the PAG in male but not female rats. Given that morphine antinociception is produced in part by disinhibition of PAG output neurons, it is hypothesized that a differential activation of PAG output neurons mediates the sexually dimorphic actions of morphine. The present study examined systemic morphine-induced activation of PAG-RVM …
Role Of The Semi-Lunar Process In Locust Jumping, David W. Cofer, James Reid, Ying Zhu, Gennady Cymbalyuk, William J. Heitler, Donald H. Edwards
Role Of The Semi-Lunar Process In Locust Jumping, David W. Cofer, James Reid, Ying Zhu, Gennady Cymbalyuk, William J. Heitler, Donald H. Edwards
Neuroscience Institute Faculty Publications
We have developed a software toolkit, AnimatLab, which allows researchers to build and test virtual organisms. We used this software to build a virtual locust, and then asked how the semi-lunar process is utilized during jumping, and how manipulation or removal of the virtual SLP influences jump dynamics.
Confidence Intervals For Individualized Performance Models, Hans P. A. Van Dongen, Christopher G. Mott, Jen-Kuang Huang, Daniel J. Millicone, Frederic D. Mckenzie, David F. Dinges
Confidence Intervals For Individualized Performance Models, Hans P. A. Van Dongen, Christopher G. Mott, Jen-Kuang Huang, Daniel J. Millicone, Frederic D. Mckenzie, David F. Dinges
Mechanical & Aerospace Engineering Faculty Publications
Commentary on Reifman J; Rajaraman S; Gribok AV. Moving Towards Individualized Performance Models. Sleep 2007;30(9):1081-82.
Law, Responsibility, And The Brain, Owen D. Jones, Hakwan C. Lau, Dean Mobbs, Christopher D. Frith
Law, Responsibility, And The Brain, Owen D. Jones, Hakwan C. Lau, Dean Mobbs, Christopher D. Frith
Vanderbilt Law School Faculty Publications
This article addresses new developments in neuroscience, and their implications for law. It explores, for example, the relationships between brain injury and violence, as well as the connections between mental disorders and criminal behaviors. It discusses a variety of issues surrounding brain fingerprinting, the use of brain scans for lie detection, and concerns about free will. It considers the possible uses for, and legal implications of, brain-imaging technology. And it also identifies six essential limits on the use of brain imaging in courtroom procedures.
Bad Nature, Bad Nurture, And Testimony Regarding Maoa And Slc6a4 Genotyping In Murder Trials, Nita A. Farahany, William Bernet, Cindy L. Vnencak-Jones, Stephen A. Montgomery
Bad Nature, Bad Nurture, And Testimony Regarding Maoa And Slc6a4 Genotyping In Murder Trials, Nita A. Farahany, William Bernet, Cindy L. Vnencak-Jones, Stephen A. Montgomery
Faculty Scholarship
Recent research—in which subjects were studied longitudinally from childhood until adulthood—has started to clarify how a child’s environment and genetic makeup interact to create a violent adolescent or adult. For example, male subjects who were born with a particular allele of the monoamine oxidase A gene and also were maltreated as children had a much greater likelihood of manifesting violent antisocial behavior as adolescents and adults. Also, individuals who were born with particular alleles of the serotonin transporter gene and also experienced multiple stressful life events were more likely to manifest serious depression and suicidality. This research raises the question …
Law, Responsibility, And The Brain, Owen D. Jones, Dean Mobbs, Hakwan C. Lau, Christopher D. Frith
Law, Responsibility, And The Brain, Owen D. Jones, Dean Mobbs, Hakwan C. Lau, Christopher D. Frith
Vanderbilt Law School Faculty Publications
This article addresses new developments in neuroscience, and their implications for law. It explores, for example, the relationships between brain injury and violence, as well as the connections between mental disorders and criminal behaviors. It discusses a variety of issues surrounding brain fingerprinting, the use of brain scans for lie detection, and concerns about free will. It considers the possible uses for, and legal implications of, brain-imaging technology. And it also identifies six essential limits on the use of brain imaging in courtroom procedures.
Optimization Of Biomathematical Model Predictions For Cognitive Performance Impairment In Individuals: Accounting For Unknown Traits And Uncertain States In Homeostatic And Circadian Processes, Hans P. A. Van Dongen, Christopher G. Mott, Jen-Kuang Huang, Daniel J. Mollicone, Frederic D. Mckenzie, David F. Dinges
Optimization Of Biomathematical Model Predictions For Cognitive Performance Impairment In Individuals: Accounting For Unknown Traits And Uncertain States In Homeostatic And Circadian Processes, Hans P. A. Van Dongen, Christopher G. Mott, Jen-Kuang Huang, Daniel J. Mollicone, Frederic D. Mckenzie, David F. Dinges
Mechanical & Aerospace Engineering Faculty Publications
Current biomathematical models of fatigue and performance do not accurately predict cognitive performance for individuals with a priori unknown degrees of trait vulnerability to sleep loss, do not predict performance reliably when initial conditions are uncertain, and do not yield statistically valid estimates of prediction accuracy, These limitations diminish their usefulness for predicting the performance of individuals in operational environments. To overcome these 3 limitations, a novel modeling approach was developed, based on the expansion of a statistical technique called Bayesian forecasting. The expanded Bayesian forecasting procedure was implemented in the two-process model of sleep regulation, which has been used …