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The Impact Of Perineuronal Net Digestion Using Chondroitinase Abc On The Intrinsic Physiology Of Cortical Neurons, Philip Chu, Reena Abraham, Kumarie Budhu, Usma Khan, Natalie De Marco Garcia, Joshua C. Brumberg

Publications and Research

Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNNs expression around somas, proximal dendrites, and axon initial segments of a subtype of neurons have also led to proposals that PNNs may modulate the intrinsic properties of the neurons they ensheathe. While high levels of PNNs are postnatally expressed throughout the neocortex, it is still unclear how they impact the neuronal physiology of the many classes and subtypes of …