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Identification Of Three Novel Genes, Ppk12, Ppk23, And Ppk25, Involved In Noxious Cold Detection In Drosophila, Benjamin Williamson
Identification Of Three Novel Genes, Ppk12, Ppk23, And Ppk25, Involved In Noxious Cold Detection In Drosophila, Benjamin Williamson
Masters Theses, 2010-2019
The reflexive response and perception of pain (nociception) is an evolutionarily conserved process in animals. Pain can be a major health concern and current treatments often prove insufficient, especially in regards to chronic pain. Greater understanding of the molecular processes underlying pain sensation could lead to new and more effective treatments. The aim of this study is to investigate the molecular mechanisms of cold nociception in Drosophila melanogaster. A specific subset of peripheral sensory neurons (Class III dendritic arborization (da) neurons), are implicated in Drosophila larvae’s response to noxious cold.
Previous literature has implicated a variety of ion channel families, …