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The Role Of The Prefrontal Cortex And Stress In Huntington Disease-Mediated Aggression, Kadambari Vyas
The Role Of The Prefrontal Cortex And Stress In Huntington Disease-Mediated Aggression, Kadambari Vyas
Honors Undergraduate Theses
Huntington Disease (HD) is a fatal neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric symptoms. Although HD onset is determined by motor symptoms, psychiatric symptoms, like depression and aggression, can develop earlier, have a larger impact on quality of life, and are understudied due to stigma. Our lab has observed hyper aggression in our humanized HD mouse model (Hu97/18) compared to our knock-in HD mouse model (Q175FDN). We characterized these differences and found that the Hu97/18 mice overreact in neutral situations, behaving as if they are in threatening situations. We are now using this novel model of HD-related …