Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Estrodial Effects On Age-Related Shifts In Learning And Memory: A Multiple Memory Systems Approach, Luis Castelan
Estrodial Effects On Age-Related Shifts In Learning And Memory: A Multiple Memory Systems Approach, Luis Castelan
Honors Capstone Projects - All
Many findings from our lab and others suggest that circulating estrogens as well as estrogen replacement after ovariectomy influence cognitive performance. Young female rats trained during proestrus, when estrogens are high, or with acute estradiol (E2) administration after ovariectomy perform better on the hippocampus-sensitive place task but worse on the striatum-sensitive response task (Korol et al., 2004; Korol and Kolo, 2002). Behavioral neuroscience studies tend to use male rodent models to avoid the complexities of the female reproductive cycle, producing a gap in our knowledge about neural mechanisms of learning and memory in females. As a consequence, age-related effects of …
Differential Activation Of Microglia In An In Vitro Model Of Intracerebral Hemorrhage, Bhakti Patel
Differential Activation Of Microglia In An In Vitro Model Of Intracerebral Hemorrhage, Bhakti Patel
Honors Capstone Projects - All
An in vitro model of intracerebral hemorrhage was established to examine the protective versus cytotoxic roles of microglia in the context of mild versus severe injury. Co-cultures of microglia, astrocytes, and granule neurons were prepared from the cerebellar cortex of neonatal rats, and grown in standard medium containing fetal bovine serum or, in some cases, a serum-free chemically defined medium. To mimic hemorrhagic stroke, co-cultures grown for 7-8 days in vitro were challenged with two different concentrations of the toxic blood product hemin, corresponding to a mild versus a severe brain bleed. Immunocyto-chemical, real-time RT-PCR, iron deposition, and cell survival …
An Exploration Of The Societal Impact Of Neuroethics In Scientific And General Communities, Katelyn Marie Edel
An Exploration Of The Societal Impact Of Neuroethics In Scientific And General Communities, Katelyn Marie Edel
Honors Capstone Projects - All
Neuroethics serves as a roadmap for maneuvering the difficult and often personal concerns that arise concurrently with advancements in neuroscience. It is important to consider these issues at present and to take a proactive, rather than reactive, approach towards assuaging fears and hesitations related to the quickening applications of neuroscience into the non-scientific community. This Capstone explores recent suggestions made by prominent scholars in the neuroethics field related to the integration of neuroscience into society. Three cogent issues in neuroscience are discussed, with a focus on the possible effects that neuroscientific advancements have on society. Using a framework of human …
Exercise-Induced Adult Neruogenesis And The Seizure Threshold: The Role Of Cox-2, Gina Kim
Exercise-Induced Adult Neruogenesis And The Seizure Threshold: The Role Of Cox-2, Gina Kim
Honors Capstone Projects - All
Neurogenesis, the generation of new neurons, is most prevalent when the brain is being formed during pre-natal development. However, this process continues in select areas in the brain during adult life as well. One such area in the brain is the dentate gyrus (DG) of the hippocampus, an area known to be associated with learning and memory. In this region, neurogenesis is believed to contribute to neuroplasticity as well as improving its functions in learning and memory. Interestingly, this synthesis of neurons is increased by physical activity—predominantly running—and by seizures originating in the limbic system. The increased excitatory neuronal activity …