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Functional Loss Of Cntnap2 In The Rat Leads To Autism-Related Alterations In Behaviour And Auditory Processing, Kaela Elizabeth Scott
Functional Loss Of Cntnap2 In The Rat Leads To Autism-Related Alterations In Behaviour And Auditory Processing, Kaela Elizabeth Scott
Electronic Thesis and Dissertation Repository
The contactin-associated protein-like 2 gene, CNTNAP2, is a highly penetrant gene thought to play a role in the genetic etiology of neurodevelopmental disorders such as autism spectrum disorder (ASD). Despite its link to ASD, the field lacks a complete understanding of the role CNTNAP2 plays in the hallmarks of ASD: repetitive behaviours and abnormalities in social interaction, language, and sensory processing. Therefore, this thesis first examines if a loss-of-function mutation in the CNTNAP2 gene in the rat (SD-Cntnap2tm1Sage) is sufficient to cause alterations in social interactions, stereotypic behaviour, and sensory processing. Cntnap2 knockout rats showed deficits …