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Early Experience And The Functional Calibration Of The Stress-Response Systems, Niki Hosseini-Kamkar
Early Experience And The Functional Calibration Of The Stress-Response Systems, Niki Hosseini-Kamkar
Electronic Thesis and Dissertation Repository
Individuals exposed to adversities in childhood are at a greater risk of developing various diseases as adults, including cardiovascular disease and cancer (Felitti et al. 1998). These findings have sparked an interest in examining biological mechanisms that might explain the link between exposure to adversity and disease. To date, evidence has linked adversity to the function of the hypothalamic-pituitary-adrenal (HPA) axis. More recently, adversity has been associated with the function of the mesolimbic dopamine pathway as well.
This thesis uses a variety of techniques to explore the association between adversity and the function of the HPA axis and mesolimbic dopamine …