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The Effect Of Aging On The Blood Brain Barrier Permeability And Response To Fluoxetine Enantiomers, Ethar Arkan
The Effect Of Aging On The Blood Brain Barrier Permeability And Response To Fluoxetine Enantiomers, Ethar Arkan
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We tested the effect of the fluoxetine enantiomers (S-fluoxetine and R-fluoxetine) versus Prozac (50:50 ratio of R- and S- fluoxetine enantiomers) and/or control on blood brain barrier (BBB) permeability in different brain regions in both male and female rats. The rats consumed orally the drug (5 mg/kg) or vehicle for a total of three days, then were injected with sterile Evans blue dye ip, at least 12 hours before euthanasia.. We see significant regional brain differences in BBB permeability (hippocampus has tighter BBB), significant differences based on the age of the animals (young rats show enhanced permeability in lower brain …