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Full-Text Articles in Life Sciences
Dbx1 Precursor Cells Are A Source Of Inspiratory Xii Premotoneurons., Ann L. Revill, Nicolas C. Vann, Victoria T. Akins, Andrew Kottick, Paul A. Gray, Christopher A. Del Negro, Gregory D. Funk
Dbx1 Precursor Cells Are A Source Of Inspiratory Xii Premotoneurons., Ann L. Revill, Nicolas C. Vann, Victoria T. Akins, Andrew Kottick, Paul A. Gray, Christopher A. Del Negro, Gregory D. Funk
Arts & Sciences Articles
All behaviors require coordinated activation of motoneurons from central command and premotor networks. The genetic identities of premotoneurons providing behaviorally relevant excitation to any pool of respiratory motoneurons remain unknown. Recently, we established in vitro that Dbx1-derived pre-Bo¨ tzinger complex neurons are critical for rhythm generation and that a subpopulation serves a premotor function (Wang et al., 2014). Here, we further show that a subpopulation of Dbx1-derived intermediate reticular (IRt) neurons are rhythmically active during inspiration and project to the hypoglossal (XII) nucleus that contains motoneurons important for maintaining airway patency. Laser ablation of Dbx1 IRt neurons, 57% of which …
Mechanisms Leading To Rhythm Cessation In The Respiratory Prebotzinger Complex Due To Piecewise Cumulative Neuronal Deletions, Hanbing Song, John A. Hayes, Nicolas A. Vann, M. Drew Lamar, Christopher A. Del Negro
Mechanisms Leading To Rhythm Cessation In The Respiratory Prebotzinger Complex Due To Piecewise Cumulative Neuronal Deletions, Hanbing Song, John A. Hayes, Nicolas A. Vann, M. Drew Lamar, Christopher A. Del Negro
Arts & Sciences Articles
The brainstem pre-Botzinger complex (preBotC) generates the rhythm underlying inspiratory breathing movements and its core interneurons are derived from Dbx-1 expressing precursors. Recurrent synaptic excitation is required to initiate inspiratory bursts, but whether excitatory synaptic mechanisms also contribute to inspiratory–expiratory phase transition is unknown. Here, we examined the role of short-term synaptic depression using a rhythmically active neonatal mouse brainstem slice preparation. We show that different axonal projections to Dbx-1 PreBotC neurons undergo activity-dependent depression and we identify a refractory period (approx. 2 s) after endogenous inspiratory bursts that precludes light-evoked bursts in channelrhodopsin-expressing Dbx1 Pre-BotC neurons. We demonstrate that …
Neurocognitive Mechanisms Of Social Influence On Emotion, Emily Catherine Willroth
Neurocognitive Mechanisms Of Social Influence On Emotion, Emily Catherine Willroth
Dissertations, Theses, and Masters Projects
No abstract provided.
Neurotransmitter Systems And Age Related Cognitive Decline: A Focus On Attention And Plasticity, Christine Teal Kozikowski
Neurotransmitter Systems And Age Related Cognitive Decline: A Focus On Attention And Plasticity, Christine Teal Kozikowski
Dissertations, Theses, and Masters Projects
No abstract provided.