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Co-Morbidity Of Alzheimer’S Disease And Stroke: Cognitive Deficits And Cellular Pathologies In Two Co-Morbid Animal Models, Jennifer L. Au
Co-Morbidity Of Alzheimer’S Disease And Stroke: Cognitive Deficits And Cellular Pathologies In Two Co-Morbid Animal Models, Jennifer L. Au
Electronic Thesis and Dissertation Repository
Prior to beta-amyloid (Aβ) protein accumulation into plaques in Alzheimer’s disease (AD), neuroinflammation and oxidative stress have been shown to contribute to early cognitive decline. These cellular pathologies are coincident in stroke, which is considered a risk factor for AD. This study investigated the co-morbid effects of AD and stroke on behavioural and cellular pathology in two rodent models. Motor function, memory and microglial neuroinflammation were investigated in a stroke and Aβ injection model and mutant human amyloid precursor protein (APP) transgenic model with stroke. Injections of endothelin-1 into the right striatum were used to model stroke and AD was …