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Neurodevelopmental Roles Of Semaphorin6a/Plexina2 Signaling In Zebrafish, Sarah Elizabeth Emerson
Neurodevelopmental Roles Of Semaphorin6a/Plexina2 Signaling In Zebrafish, Sarah Elizabeth Emerson
Graduate College Dissertations and Theses
ABSTRACT
A multitude of complex cellular changes are required throughout development in order for a single cell to transform into a fully functioning organism. Cellular events including proliferation, migration, and differentiation have to be carefully controlled in order for development to proceed correctly. In order to study such dynamic processes, in vivo models are often utilized. Using the zebrafish (Danio rerio) as a model system, we have investigated the role of an axon guidance signaling pair, Semaphorin6A (Sema6A) and PlexinA2 (PlxnA2), in neurodevelopment.
A previous investigation into the developmental expression patterns of sema6A and plxnA2 in zebrafish, revealed overlapping expression …