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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Protein Kinase Mzeta (Pkm-Ζ) Regulates Kv1.2 Dependent Cerebellar Eyeblink Classical Conditioning, Kutibh Chihabi
Protein Kinase Mzeta (Pkm-Ζ) Regulates Kv1.2 Dependent Cerebellar Eyeblink Classical Conditioning, Kutibh Chihabi
Graduate College Dissertations and Theses
Learning and memory has been a topic that has captured the attention of the scientific and public communities since the dawn of scientific discovery. Without the faculty of memory, mammals cannot experience nor function in the world; among homosapiens specifically, language, relationships, and personal identity cannot be developed (Eysenck, 2012). After all, some philosophers such as John Locke argued we are nothing but a collection of past memories in which we have developed and improved upon (Nimbalkar, 2011).
Understanding the cellular mechanisms behind learning, and the subsequent formation of memory, has been a topic that has garnered scientific interest for …
The Biochemical Characterization Of Human Histidyl-Trna Synthetase And Disease Associated Variants, Jamie Alyson Abbott
The Biochemical Characterization Of Human Histidyl-Trna Synthetase And Disease Associated Variants, Jamie Alyson Abbott
Graduate College Dissertations and Theses
Human histidyl-tRNA synthetase (HARS) is an aminoacyl-tRNA synthetase (AARS) that catalyzes the attachment of the amino acid histidine to histidyl-tRNA (tRNAHis) in a two-step reaction that is essential for protein translation. Currently, two human diseases, Usher Syndrome IIIB (USH3B) and an inherited peripheral neuropathy, Charcot Marie Tooth Syndrome (CMT), have been linked genetically to single point mutations in the HARS gene. The recessive HARS USH3B mutation encodes an Y454S substitution localized at the interface between the anticodon-binding domain and the catalytic domain of the opposing subunit. Patients with Usher Syndrome IIIB lose their sight and hearing during their second decade …
Co-Localization Of Basal And Proliferative Cells In The Murine Main Olfactory Epithelium And Vomeronasal Organ After Injury With Cyclophosphamide, Kyle Barnes Joseph
Co-Localization Of Basal And Proliferative Cells In The Murine Main Olfactory Epithelium And Vomeronasal Organ After Injury With Cyclophosphamide, Kyle Barnes Joseph
Graduate College Dissertations and Theses
ABSTRACT
In humans, advanced malignancies are often targeted with broad-spectrum cytotoxic drugs that engender several detrimental side effects, in addition to their primary usage for eradicating cancerous cells. One of the lesser-researched of these effects, histological distortion of the olfactory system impedes a patient's ability to smell, perceive flavor, and ultimately may interfere with their nutritional intake and recovery from chemotherapy. Recent studies have indicated that cytotoxic drugs can damage gustatory epithelia immediately following administration (Mukherjee & Delay, 2011, 2013). We sought to observe the histological effects that cyclophosphamide (CYP), one of the oldest and most popular alkylating antineoplastic agents, …
Predictive Modeling Of Adolescent Cannabis Use From Multimodal Data, Philip Spechler
Predictive Modeling Of Adolescent Cannabis Use From Multimodal Data, Philip Spechler
Graduate College Dissertations and Theses
Predicting teenage drug use is key to understanding the etiology of substance abuse. However, classic predictive modeling procedures are prone to overfitting and fail to generalize to independent observations. To mitigate these concerns, cross-validated logistic regression with elastic-net regularization was used to predict cannabis use by age 16 from a large sample of fourteen year olds (N=1,319). High-dimensional data (p = 2,413) including parent and child psychometric data, child structural and functional MRI data, and genetic data (candidate single-nucleotide polymorphisms, "SNPs") collected at age 14 were used to predict the initiation of cannabis use (minimum six occasions) by age 16. …
Imaging Pain And Brain Plasticity: A Longitudinal Structural Imaging Study, James Hart Bishop
Imaging Pain And Brain Plasticity: A Longitudinal Structural Imaging Study, James Hart Bishop
Graduate College Dissertations and Theses
Chronic musculoskeletal pain is a leading cause of disability worldwide yet the mechanisms of chronification and neural responses to effective treatment remain elusive. Non-invasive imaging techniques are useful for investigating brain alterations associated with health and disease. Thus the overall goal of this dissertation was to investigate the white (WM) and grey matter (GM) structural differences in patients with musculoskeletal pain before and after psychotherapeutic intervention: cognitive behavioral therapy (CBT). To aid in the interpretation of clinical findings, we used a novel porcine model of low back pain-like pathophysiology and developed a post-mortem, in situ, neuroimaging approach to facilitate translational …