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Full-Text Articles in Life Sciences
Direct Reprogramming Of Mouse Embryonic Fibroblasts Into Gabaergic Neurons, Nicholas J. Wasko
Direct Reprogramming Of Mouse Embryonic Fibroblasts Into Gabaergic Neurons, Nicholas J. Wasko
Honors Scholar Theses
Recent studies in which mouse and human fibroblasts were directly reprogrammed into functional neurons have demonstrated that lineage-specific transcription factors can override differentiation processes previously thought to be irreversible. Notably, three factors have been shown to be required for the induction of neural cell fate. Subsequent experiments have identified additional factors capable of generating specific neuronal subtypes, including motor neurons and dopaminergic neurons, but the factors necessary for inducing GABAergic neuronal fate have yet to be elucidated. Here, factors linked to GABAergic fate were transfected into mouse fibroblasts in order to identify candidate factors for inhibitory interneuron direct reprogramming. Results …
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John J. Peters
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John J. Peters
Honors Scholar Theses
Previous research has shown that numerous age-related changes occur in the subventricular zone (SVZ) and diminish the neurogenic output of the region. Here, various age-related changes in the structure of the lateral ventricle, the ependymal barrier, and the SVZ were examined. It was found that the walls of the lateral ventricles move together, adhere, and eventually fuse. This results in a degradation of the SVZ. Other changes associated with aging were found, including ependymal cell stretching, heightened, ependymal repair, changes in CSF flow velocity and dynamics, and altered ependymal cell polarity. These changes may be related to the process of …
Modulation Of Synaptic Transmission By Adenosine In Layer 2/3 Of The Rat Visual Cortex In Vitro, Nicholas M. Bannon
Modulation Of Synaptic Transmission By Adenosine In Layer 2/3 Of The Rat Visual Cortex In Vitro, Nicholas M. Bannon
Master's Theses
No abstract provided.
Copper Signaling In The Mammalian Nervous System: Synaptic Effects, Eric D. Gaier, Betty A. Eipper, Richard E. Mains
Copper Signaling In The Mammalian Nervous System: Synaptic Effects, Eric D. Gaier, Betty A. Eipper, Richard E. Mains
UCHC Articles - Research
Copper (Cu) is an essential metal present at high levels in the CNS. Its role as a co-factor in mitochondrial ATP production and in other essential cuproenzymes is well defined. Menkes and Wilson’s diseases are severe neurodegenerative conditions that demonstrate the importance of Cu transport into the secretory pathway. Brain levels of Cu, which is almost entirely protein bound, exceed extracellular levels by more than a hundred-fold. Cu stored in the secretory pathway is released in a Ca2+-dependent manner and can transiently reach concentrations over 100 µM at synapses. The ability of low µM levels of Cu to …