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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Harnessing Electrocorticographic Signals For Neuroscience And Neurosurgery, Adriana De Pesters
Harnessing Electrocorticographic Signals For Neuroscience And Neurosurgery, Adriana De Pesters
Legacy Theses & Dissertations (2009 - 2024)
Daily human activities, such as speaking, driving or listening to music, are produced by activations of neurons in the brain. Where, when and how these activations occur has been the subject of intense debate for the last decades. Traditional techniques to image the human brain, such as functional magnetic resonance imaging (fMRI) or electroencephalography (EEG), only provide limited information regarding where and when these activations take place. For that reason, critical information is currently missing regarding how neurons from different parts of the brain interact and coordinate their activity to implement behavior. This information is critical to understand human behavior …
Elucidating The Transcriptional Regulation Underlying Neural Induction, Sarah E. Hirsch
Elucidating The Transcriptional Regulation Underlying Neural Induction, Sarah E. Hirsch
Legacy Theses & Dissertations (2009 - 2024)
The brain is one of the most complicated structures in the human body and its development is also elusive. Great strides have been made in expounding some of the complex mechanisms of neural development, which allows for the creation of innovative, less invasive, and more effective treatments for neurodevelopmental and neurodegenerative disorders. The advent of stem cell technology has brought therapy development for these disorders closer to a reality, as stem cells provide a platform to model early stages of human neural development. This is of great importance, as only through studying neurodevelopment will the various transcriptional and molecular components …
Analysis Of Candidate Genes For Seizure Susceptibility In Epileptogenesis, Brittany O'Brien
Analysis Of Candidate Genes For Seizure Susceptibility In Epileptogenesis, Brittany O'Brien
Legacy Theses & Dissertations (2009 - 2024)
The occurrence of recurrent spontaneous seizures is the hallmark of epilepsy. The key to understanding how a normal brain can develop epilepsy through a process known as epileptogenesis is identifying susceptibility factors. Previously, various strains of inbred mice from the hybrid mouse diversity panel were subjected to multiple seizures via the repeated flurothyl model (RFM) for epileptogenesis. The results demonstrated differences in kindling among the inbred strains; specifically two main trends in the generalized seizure threshold (GST) data were kindling-sensitive and kindling-resistant strains. In addition, genome wide association studies done from these mice demonstrated a quantitative trait locus (QTL) on …
Retinal Disease Modeling And Drug Screening Using Stem Cell Derived Retinal Pigment Epithelium, Janmeet Singh Saini
Retinal Disease Modeling And Drug Screening Using Stem Cell Derived Retinal Pigment Epithelium, Janmeet Singh Saini
Legacy Theses & Dissertations (2009 - 2024)
The eye is an intricate organ, possessing sensory receptors in the retina that are involved in visual perception. The retina consists primarily of the neural layer, referred to as the neural retina, and the pigmented layer, referred to as the retinal pigment epithelium (RPE). The neural retina and RPE develop and mature in a coordinated manner, and depend on each other for survival. In a mature healthy retina, the retinal photoreceptor outer segments interdigitate with the RPE monolayer, and they co-exchange key supportive factors. RPE cells are indispensable for the health of the retina as they are involved in a …
A Laser-Pulse Photolysis Study Of The Mechanism Of Potentiation Of The Glua2qflip Ampa Receptors By Cx546, Yu-Chuan Shen
A Laser-Pulse Photolysis Study Of The Mechanism Of Potentiation Of The Glua2qflip Ampa Receptors By Cx546, Yu-Chuan Shen
Legacy Theses & Dissertations (2009 - 2024)
Insufficient activity of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate ion channels is involved in neurological disorders and developmental problems, such as schizophrenia, one of the most serious psychiatric diseases. Use of regulatory agents to enhance AMPA receptor activity under the circumstance has been shown therapeutically beneficial. Specifically, small-molecule compounds generally termed as potentiators or positive modulators of AMPA receptors have long been pursued as drug candidates for a potential treatment of these neurological disorders and diseases. The goal of my MS thesis work is to investigate the mechanism of potentiation on AMPA receptor by a classic potentiator known as CX546. The …
Disease In A Dish : Modeling Tau Pathology For Future Antibody Testing, Leneea Toyisha Warner
Disease In A Dish : Modeling Tau Pathology For Future Antibody Testing, Leneea Toyisha Warner
Legacy Theses & Dissertations (2009 - 2024)
ABSTRACT