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Full-Text Articles in Life Sciences
Migraine And Epilepsy—Shared Mechanisms Within The Family Of Episodic Disorders, Michael A. Rogawski
Migraine And Epilepsy—Shared Mechanisms Within The Family Of Episodic Disorders, Michael A. Rogawski
Michael A. Rogawski
Migraine and epilepsy are episodic disorders that share many clinical features and underlying pathophysiological mechanisms. Cortical spreading depression (CSD), a wave of profound cellular depolarization, is believed to underlie migraine aura and to be a trigger for the headache pain in migraine. However, the initial event preceding CSD is cellular hyperexcitability associated with localized epileptiform discharges. Glutamate is a critical mediator of the hyperexcitability in both focal seizures and migraine. In focal epilepsy, seizure generation and spread is mediated by synaptically released glutamate acting on AMPA receptors, whereas triggering of CSD depends on NMDA receptors and spread does not require …
Neurosteroids—Endogenous Regulators Of Seizure Susceptibility And Role In The Treatment Of Epilepsy, Doodipala S. Reddy, Michael A. Rogawski
Neurosteroids—Endogenous Regulators Of Seizure Susceptibility And Role In The Treatment Of Epilepsy, Doodipala S. Reddy, Michael A. Rogawski
Michael A. Rogawski
Certain steroid hormone metabolites that have activity as modulators of GABA-A receptors but lack conventional hormonal effects—including allopregnanolone and allotetrahydrodeoxycorticosterone—are synthesized within the brain, predominantly in principle (excitatory) neurons, and also in peripheral tissues. At low concentrations, such neurosteroids potentiate GABA-A receptor currents, whereas at higher concentrations they directly activate the receptor; large magnitude effects occur on nonsynaptic delta subunit-containing GABA-A receptors that mediate tonic currents. GABA-A receptor modulatory neurosteroids confer seizure protection in diverse animal models, without tolerance during chronic administration. Endogenous neurosteroids may play a role in catamenial epilepsy, stress-induced changes in seizure susceptibility, temporal lobe epilepsy, and …
Mechanisms Of Action Of Antiseizure Drugs (Chapter 39), Roger J. Porter, Ashish Dhir, Robert L. Macdonald, Michael A. Rogawski
Mechanisms Of Action Of Antiseizure Drugs (Chapter 39), Roger J. Porter, Ashish Dhir, Robert L. Macdonald, Michael A. Rogawski
Michael A. Rogawski
No abstract provided.
Cellular Effects Of Antiepileptic Drugs, Robert L. Macdonald, Michael A. Rogawski
Cellular Effects Of Antiepileptic Drugs, Robert L. Macdonald, Michael A. Rogawski
Michael A. Rogawski
Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which include various ion channels, a neurotransmitter transporter, a neurotransmitter metabolic enzyme, and a synaptic vesicle protein. AED actions on these targets can be categorized into four broad groups: 1. Modulation of voltage-dependent ion channels (mainly sodium [Na] but also calcium [Ca] channels) 2. Effects on γ-aminobutyric acid (GABA) systems, including alterations in the cellular disposition of GABA and enhancement of synaptic inhibition mediated by GABA-A receptors 3. Inhibition of synaptic excitation mediated by ionotropic glutamate receptors 4. Modulation of neurotransmitter release, particularly of glutamate, through …
Epilepsy: Mechanisms Of Drug Action And Clinical Treatment, William Theodore, Michael Rogawski
Epilepsy: Mechanisms Of Drug Action And Clinical Treatment, William Theodore, Michael Rogawski
Michael A. Rogawski
No abstract provided.
Alcohol Withdrawal Seizures, Michael A. Rogawski, Prosper N'Gouemo
Alcohol Withdrawal Seizures, Michael A. Rogawski, Prosper N'Gouemo
Michael A. Rogawski
No abstract provided.
Neurosteroids: Endogenous Modulators Of Seizure Susceptibility, Michael A. Rogawski, Doodipala S. Reddy
Neurosteroids: Endogenous Modulators Of Seizure Susceptibility, Michael A. Rogawski, Doodipala S. Reddy
Michael A. Rogawski
No abstract provided.
Principles Of Antiepileptic Drug Action, Michael Rogawski
Principles Of Antiepileptic Drug Action, Michael Rogawski
Michael A. Rogawski
No abstract provided.
Epilepsy (Ionotropic Glutamate Receptors As Therapeutic Targets), Wolfgang Löscher, Michael A. Rogawski
Epilepsy (Ionotropic Glutamate Receptors As Therapeutic Targets), Wolfgang Löscher, Michael A. Rogawski
Michael A. Rogawski
No abstract provided.
Ampa Receptors In Epilepsy And As Targets For Antiepileptic Drugs, Michael A. Rogawski, Sean D. Donevan
Ampa Receptors In Epilepsy And As Targets For Antiepileptic Drugs, Michael A. Rogawski, Sean D. Donevan
Michael A. Rogawski
No abstract provided.
Excitatory Amino Acids And Seizures, Michael A. Rogawski
Excitatory Amino Acids And Seizures, Michael A. Rogawski
Michael A. Rogawski
No abstract provided.