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Full-Text Articles in Life Sciences
Interaction Between The Dorsal And Ventral Pathways In Mental Rotation: An Fmri Study, Hideya Koshino, Patricia Carpenter, Timothy Keller, Marcel Just
Interaction Between The Dorsal And Ventral Pathways In Mental Rotation: An Fmri Study, Hideya Koshino, Patricia Carpenter, Timothy Keller, Marcel Just
Marcel Adam Just
No abstract provided.
Imagining Material Versus Geometric Properties Of Objects: An Fmri Study, Sharlene Newman, Roberta Klatzky, Susan Lederman, Marcel Just
Imagining Material Versus Geometric Properties Of Objects: An Fmri Study, Sharlene Newman, Roberta Klatzky, Susan Lederman, Marcel Just
Marcel Adam Just
No abstract provided.
Nonclassical, Distinct Endocytic Signals Dictate Constitutive And Pkc-Regulated Neurotransmitter Transporter Internalization, Haley Melikian
Nonclassical, Distinct Endocytic Signals Dictate Constitutive And Pkc-Regulated Neurotransmitter Transporter Internalization, Haley Melikian
Haley Melikian
Neurotransmitter transporters are critical for synaptic neurotransmitter inactivation. Transporter inhibitors markedly increase the duration and magnitude of synaptic transmission, underscoring the importance of transporter activity in neurotransmission. Recent studies indicate that membrane trafficking dynamically governs neuronal transporter cell-surface presentation in a protein kinase C-regulated manner, suggesting that transporter trafficking profoundly affects synaptic signaling. However, the molecular architecture coupling neurotransmitter transporters to the endocytic machinery is not defined. Here, we identify nonclassical, distinct endocytic signals in the dopamine transporter (DAT) that are necessary and sufficient to drive constitutive and protein kinase C-regulated DAT internalization. The DAT internalization signal is conserved across …
Functional Connectivity In An Fmri Working Memory Task In High-Functioning Autism, Hideya Koshino, Patricia Carpenter, Nancy Minshew, Vladimir Cherkassky, Timothy Keller, Marcel Just
Functional Connectivity In An Fmri Working Memory Task In High-Functioning Autism, Hideya Koshino, Patricia Carpenter, Nancy Minshew, Vladimir Cherkassky, Timothy Keller, Marcel Just
Marcel Adam Just
No abstract provided.
Single-Channel Properties Of Human Nav1.1 And Mechanism Of Channel Dysfunction In Scn1a-Associated Epilepsy, C. Vanoye, Christoph Lossin, T. H. Rhodes, Alfred L. George
Single-Channel Properties Of Human Nav1.1 And Mechanism Of Channel Dysfunction In Scn1a-Associated Epilepsy, C. Vanoye, Christoph Lossin, T. H. Rhodes, Alfred L. George
Christoph Lossin, Ph.D.
Mutations in genes encoding neuronal voltage-gated sodium channel subunits have been linked to inherited forms of epilepsy. The majority of mutations (>100) associated with generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI) occur in SCN1A encoding the NaV1.1 neuronal sodium channel alpha-subunit. Previous studies demonstrated functional heterogeneity among mutant SCN1A channels, revealing a complex relationship between clinical and biophysical phenotypes. To further understand the mechanisms responsible for mutant SCN1A behavior, we performed a comprehensive analysis of the single-channel properties of heterologously expressed recombinant WT-SCN1A channels. Based on these data, we then determined the …
The Framing Effect And Risky Decisions: Examining Cognitive Functions With Fmri, Cleotilde Gonzalez, Jason Dana, Hideya Koshino, Marcel Adam Just
The Framing Effect And Risky Decisions: Examining Cognitive Functions With Fmri, Cleotilde Gonzalez, Jason Dana, Hideya Koshino, Marcel Adam Just
Marcel Adam Just
No abstract provided.