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Full-Text Articles in Life Sciences

Step Regulation Of Seizure Thresholds In The Hippocampus, Janice R. Naegele Nov 2012

Step Regulation Of Seizure Thresholds In The Hippocampus, Janice R. Naegele

Janice R Naegele

Purpose:  To investigate whether striatal enriched protein tyrosine phosphatase (STEP) influences ictogenesis. Methods:  STEP knockout mice were compared to wild-type (WT) mice in pilocarpine-induced seizures. Hippocampal slices were also prepared from these two mouse populations, allowing the examination of ictal-like stimulation in these slices using calcium imaging and electrophysiologic recordings. Key Findings:  To examine seizure thresholds, increasing doses of pilocarpine were administered to adult mice and seizures were scored behaviorally. Significantly fewer STEP knockout mice developed seizures that progressed to the stage of status epilepticus compared to WT mice. To examine potential differences in neural circuits that might account for …


Migration Of Transplanted Neural Stem Cells In Experimental Models Of Neurodegenerative Diseases., Janice Naegele Nov 2012

Migration Of Transplanted Neural Stem Cells In Experimental Models Of Neurodegenerative Diseases., Janice Naegele

Janice R Naegele

No abstract provided.


Tangled Roots: Digging Deeper Into Astrocyte Or Interneuron Dysfunction In Temporal Lobe Epilepsy., Janice R. Naegele Nov 2012

Tangled Roots: Digging Deeper Into Astrocyte Or Interneuron Dysfunction In Temporal Lobe Epilepsy., Janice R. Naegele

Janice R Naegele

No abstract provided.


Epilepsy And The Plastic Mind, Janice Naegele Nov 2012

Epilepsy And The Plastic Mind, Janice Naegele

Janice R Naegele

No abstract provided.


Embryonic Stem Cell Therapy For Intractable Epilepsy., Janice Naegele Dec 2011

Embryonic Stem Cell Therapy For Intractable Epilepsy., Janice Naegele

Janice R Naegele

Envisioning a world in which humans are able to regenerate severed limbs, rewire neural pathways, and enhance sensory perception has been a mainstay of science fiction novels and movies for decades. While human limb regeneration is still not possible, remarkable developments in the fields of stem cell biology and neuroscience are leading the way for stem cell-based therapies to amend brain and spinal cord damage and repair sensory organs. In this chapter, we discuss recent efforts to derive neural stem cells from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) and their applications to treating conditions such as …