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Zmp-Induced Activation Of Ampk Enhances Accumbal Dopamine Function, Isabella Roque, Jordan Yorgason, Rachel Campbell, Serin Baker, Jared Mcfarlane, Oliver Saunders, David Thomson
Zmp-Induced Activation Of Ampk Enhances Accumbal Dopamine Function, Isabella Roque, Jordan Yorgason, Rachel Campbell, Serin Baker, Jared Mcfarlane, Oliver Saunders, David Thomson
Library/Life Sciences Undergraduate Poster Competition 2024
Oral Presentation Honorable Mention
• Dopamine terminal function is associated with motivation
• Fasting activates AMPK, a cellular sensor that measures intracellular AMP relative to ATP
• AMPK activation is a target of interest for age related cognitive decline, prevention of muscle wasting, etc.
• ZMP is an endogenous nucleotide AMP mimetic that activates AMPK
• The present study examined the novel precursor ZMP compound called P39 using an ex vivo mouse model