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Full-Text Articles in Life Sciences
Effects Of Resting State On Perceptual Learning, Sarah Eagleman Ph.D.
Effects Of Resting State On Perceptual Learning, Sarah Eagleman Ph.D.
Dissertations & Theses (Open Access)
Psychophysical experiments in humans have demonstrated that improvements in perceptual learning tasks occur following daytime rests. The neural correlates of how rest influences subsequent sensory processing during these tasks remain unclear. One possible neural mechanism that may underlie this behavioral improvement is reactivation. Previously evoked network activity reoccurs – reactivates - in the absence of further stimulation. Reactivation was initially discovered in the hippocampus but has now been found in several brain areas including cortex. This phenomenon has been implicated as a general mechanism by which neural networks learn and store sensory information. However, whether reactivation occurs in areas relevant …
Understanding Melatonin Receptor Pharmacology: Latest Insights From Mouse Models, And Their Relevance To Human Disease, Gianluca Tosini, Sharon Owino, Jean Luc Guillaume, Ralf Jockers
Understanding Melatonin Receptor Pharmacology: Latest Insights From Mouse Models, And Their Relevance To Human Disease, Gianluca Tosini, Sharon Owino, Jean Luc Guillaume, Ralf Jockers
Neuroscience: Faculty Publications
Melatonin, the neuro-hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes development, visual functions, sleep disturbances, and depression. Transgenic mouse models were instrumental for the establishment of the link between melatonin and these major human diseases. Most of the actions of melatonin are mediated by two types of G protein-coupled receptors, named MT1 and MT2, which are expressed in many different organs and tissues. Understanding the pharmacology and function of mouse MT1 and MT2 receptors, including MT1/MT2 heteromers, will be of crucial importance to evaluate the relevance of these mouse …