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Gene Co-Expression Analysis Of The Human Substantia Nigra Identifies Bmp2 As A Neurotrophic Factor That Can Promote Neurite Growth In Cells Overexpressing Wild-Type Or A53t Α-Synuclein, Susan R. Goulding, Aideen M. Sullivan, Gerard W. O'Keeffe, Louise M. Collins
Gene Co-Expression Analysis Of The Human Substantia Nigra Identifies Bmp2 As A Neurotrophic Factor That Can Promote Neurite Growth In Cells Overexpressing Wild-Type Or A53t Α-Synuclein, Susan R. Goulding, Aideen M. Sullivan, Gerard W. O'Keeffe, Louise M. Collins
Department of Biological Sciences Publications
Introduction: α-synuclein-induced degeneration of dopaminergic neurons has been proposed to be central to the early progression of Parkinson's disease. This highlights the need to identify factors that are neuroprotective or neuroregenerative against α-synuclein-induced degeneration. Due to their potent neurotrophic effects on nigrostriatal dopaminergic neurons, we hypothesized that members of the bone morphogenetic protein (BMP) family have potential to protect these cells against α-synuclein. Methods: To identify the most relevant BMP ligands, we used unbiased gene co-expression analysis to identify all BMP family members having a significant positive correlation with five markers of dopaminergic neurons in the human substantia nigra (SN). …