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Optogenetic Interrogation Of Hippocampal Circuit Stabilization, Laurel Watkins De Jong
Optogenetic Interrogation Of Hippocampal Circuit Stabilization, Laurel Watkins De Jong
Theses and Dissertations
Understanding the response of excitatory and inhibitory populations to varying input is vital to understanding how a brain region transforms information. Optogenetics - the combined use of optics and genetics to control the activity of proteins, provides neuroscientists with a tool to interrogate neuronal circuits with high spatio-temporal resolution and targeted cell specificity. This thesis examines the effects of optogenetic manipulations on hippocampal circuit responses. The hippocampus is a structure required for the formation and retention of episodic memories and is comprised of anatomically distinct subregions including cornu ammonis 3 (CA3) and cornu ammonis 1 (CA1). Both regions, despite differences …
Electrophysiological And Morphological Characterization Of Neurons In The Granular Retrosplenial Cortex, Andrew Nicholas Nye
Electrophysiological And Morphological Characterization Of Neurons In The Granular Retrosplenial Cortex, Andrew Nicholas Nye
Theses and Dissertations
The retrosplenial cortex (RSC) is a centrally located brain region that has reciprocal connections with several brain regions important for memory, including the prefrontal cortex, para-hippocampal region, hippocampal formation, and rhinal cortices. The RSC is also well connected with structures important for sensory processing, including the parietal cortex, thalamus, and visual cortices. Due to this connectivity, and early evidence that suggests the RSC plays a critical role in learning and memory, the region has recently gained much more research attention. Early studies found that patients with brain damage that includes the RSC have difficulty with verbal and visual information, retrieving …