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The Role Of Napping On Memory Consolidation In Preschool Children, Laura Kurdziel
The Role Of Napping On Memory Consolidation In Preschool Children, Laura Kurdziel
Doctoral Dissertations
Nocturnal sleep has been shown to benefit memory in adults and children. During the preschool age range (~3-5 years), the distribution of sleep across the 24-hour period changes dramatically. Children transition from biphasic sleep patterns (a nap in addition to overnight sleep) to a monophasic sleep pattern (only overnight sleep). In addition, early childhood is a time of neuronal plasticity and pronounced acquisition of new information. This dissertation sought to examine the relationship between daytime napping and memory consolidation in preschool-aged children during this transitional time. Children were taught either a declarative or an emotional task in the morning, and …
Novel Strategies To Modulate Synaptic Communication And Investigate The Role Of Hdac6 In Alzheimer’S Disease, Kathryne A. Medeiros
Novel Strategies To Modulate Synaptic Communication And Investigate The Role Of Hdac6 In Alzheimer’S Disease, Kathryne A. Medeiros
Doctoral Dissertations
Neuronal communication is mediated by chemical signaling at the synapse. The underlying molecular mechanisms of learning and memory are poorly understood. Very few tools are available to study how memories are formed in the mammalian brain. This dissertation focuses on developing novel strategies to study neural activity. Here we develop and use a chemical-genetic approach to enable target-specific photocontrol of inhibitory synaptic neurotransmission of GABAA receptor subtypes. The tools developed here selectively photocontrolled GABAA receptor subtypes. This enabled the investigation of the functional role these receptor subtypes have in inhibitory synaptic neurotransmission. This dissertation also focuses on identifying …