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Full-Text Articles in Life Sciences
Effects Of The Antidepressant Drug Vortioxetine On Ventral Pallidal Neuronal Activity, Respiration, And Heart Rate In The Rat, Piper Rogers
Effects Of The Antidepressant Drug Vortioxetine On Ventral Pallidal Neuronal Activity, Respiration, And Heart Rate In The Rat, Piper Rogers
Theses and Dissertations
Major Depressive Disorder (MDD) is a mental illness that affects millions of people worldwide. People diagnosed with MDD are often prescribed antidepressant drugs. Most antidepressants increase levels of serotonin (5-hydroxytryptamine, 5-HT) in the synapses between neurons. Selective-serotonin reuptake inhibitors (SSRIs), one class of antidepressants, do this by inhibiting the reuptake of serotonin released into the synapse. Serotonin neurons from the brainstem raphe nuclei affect a wide range of areas throughout the brain. Among these areas is the ventral pallidum (VP), located in the basal forebrain. Citalopram, an SSRI, has been found to increase the firing rate of action potentials of …
A Combinatorial Premotor Neural Code: Transformation Of Sensory Information Into Meaningful Rhythmic Motor Output By A Network Of Heterogeneous Modulatory Neurons, Christopher John Goldsmith
A Combinatorial Premotor Neural Code: Transformation Of Sensory Information Into Meaningful Rhythmic Motor Output By A Network Of Heterogeneous Modulatory Neurons, Christopher John Goldsmith
Theses and Dissertations
The goal of the following research was to investigate the contributions of neural networks in selecting distinct variants of rhythmic motor activity. We used the premotor commissural ganglion (CoG) in the stomatogastric nervous system of the Jonah crab to understand how this network effectively controls the rhythms produced in downstream motor circuits. Prior research determined that individual CoG neurons are necessary to mediate sensory-induced variation in the effected motor patterns. However, single premotor neuron inputs to the STG are not sufficient to recreate the patterns induced by the selective activation of sensory pathways. Thus, it was hypothesized that the CoG-mediated …
An In Vivo Assay For Simultaneous Monitoring Of Neuronal Activity And Behavioral Output In The Stomatogastric Nervous System Of Decapod Crustaceans, Wolfgang Stein, Florian Diehl
An In Vivo Assay For Simultaneous Monitoring Of Neuronal Activity And Behavioral Output In The Stomatogastric Nervous System Of Decapod Crustaceans, Wolfgang Stein, Florian Diehl
Faculty Publications – Biological Sciences
Central pattern generators (CPGs) generate rhythmic output patterns and drive vital behaviors such as breathing, swallowing, locomotion and chewing 1-10. While most insights into the rhythm generating mechanisms of CPGs have been derived from isolated nervous system preparations, the relationship between neural activity and corresponding behavioral expression is often unclear. The stomatogastric system of decapod crustaceans is one of the best characterized neural system for motor pattern generation 9-12 and many mechanisms of motor pattern generation and selection have been discovered in this system. Since most studies are limited to the isolated nervous system, little is known about the …