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Full-Text Articles in Life Sciences
Peripheral Modulation Of Cardiac Contractions In The American Lobster, Homarus Americanus, By The Peptide Myosuppressin Is Mediated By Effects On The Cardiac Muscle Itself, Isabel Stella Petropoulos
Peripheral Modulation Of Cardiac Contractions In The American Lobster, Homarus Americanus, By The Peptide Myosuppressin Is Mediated By Effects On The Cardiac Muscle Itself, Isabel Stella Petropoulos
Honors Projects
A substantial factor for behavioral flexibility is modulation — largely via neuropeptides — which occurs at multiple sites including neurons, muscles, and the neuromuscular junction (NMJ). Complex modulation distributed across multiple sites provides an interesting question: does modulation at multiple locations lead to greater dynamics than one receptor site alone? The cardiac neuromuscular system of the American lobster (Homarus americanus), driven by a central pattern generator called the cardiac ganglion (CG), is a model system for peptide modulation. The peptide myosuppressin (pQDLDHVFLRFamide) has been shown in the whole heart to decrease contraction frequency, largely due to its effects on …
Characterizing And Investigating The Electrophysiological Properties Of The Plastic Cricket Auditory System In Response To Cooling, Hannah Tess Scotch
Characterizing And Investigating The Electrophysiological Properties Of The Plastic Cricket Auditory System In Response To Cooling, Hannah Tess Scotch
Honors Projects
The auditory system of the Mediterranean field cricket (Gryllus bimaculatus) is capable of profound compensatory plasticity. Following deafferentation due to the loss of an auditory organ, the dendrites of intermediate auditory neuron Ascending Neuron 2 (AN-2) grow across the midline and functionally connect to contralateral afferents. The loss of the auditory organ can be mimicked with reversible cold-deactivation, in which cooled Peltier elements silence the auditory organ and its afferents. Though this would presumably prevent AN-2 from firing, cooling instead induces a novel firing pattern called DOPE (delayed-onset, prolonged-excitation). In this study, intracellular physiological recordings were completed before, …
Responses Of Central Pattern Generators In The American Lobster Stns To Multiple Members Of A Novel Neuropeptide Family, Benjamin Harley Wong
Responses Of Central Pattern Generators In The American Lobster Stns To Multiple Members Of A Novel Neuropeptide Family, Benjamin Harley Wong
Honors Projects
Neuropeptides are important modulators of neural activity, allowing neural networks, such as the central pattern generators (CPGs) that control rhythmic movements, to alter their output and thus generate behavioral flexibility. Isoforms of a neuropeptide family vary in physical structure, allowing potentially distinct functional neuromodulatory effects on CPG systems. While some familial neuropeptide isoforms can differentially affect a system, others in the same family may elicit indistinguishable effects. Here, we examined the effects elicited by members of a novel family of six peptide hormone isoforms (GSEFLamides: I-, M-, AL-, AM-, AV-, and VM-GSEFLamide) on the pyloric filter and gastric mill CPGs …