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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
The Hippocampus Participates In A Pharmacological Rat Model Of Absence Seizures, Justin Andrew Arcaro
The Hippocampus Participates In A Pharmacological Rat Model Of Absence Seizures, Justin Andrew Arcaro
Electronic Thesis and Dissertation Repository
The thalamocortical network is responsible for the generation of spike-and-wave discharges (SWDs) in absence epilepsy. Recent studies suggest a potential involvement of the hippocampus, which may explain the variability in the extent of cognitive deficits among patients with absence epilepsy. I hypothesize that the hippocampus may become entrained in spike-and-wave discharges following thalamocortical activation. The gamma-butyrolactone (GBL) rat model of absence seizures was used in this thesis. Following GBL injection, SWDs of 4 to 6 Hz developed in the spontaneous local field potentials (LFPs) recorded by depth electrodes in the thalamus, neocortex and hippocampus. Synchronization of hippocampal, thalamic and neocortical …
Investigation Of Sox9 Ablation On Neural Stem Cell Behaviour After Spinal Cord Injury, Stephen Mcdonald
Investigation Of Sox9 Ablation On Neural Stem Cell Behaviour After Spinal Cord Injury, Stephen Mcdonald
Electronic Thesis and Dissertation Repository
After spinal cord injury neural stem cells are activated to proliferate and differentiate primarily into astrocytes, but are unable to replace lost neurons or aid in neurological recovery. Recent research shows that the transcription factor Sox9 promotes gliogenesis while inhibiting neurogenesis, and that Sox9 ablation causes improved recovery after spinal cord injury. The purpose of this study was to determine how Sox9 ablation alters neural stem cell behaviour after spinal cord injury and whether it leads to neurological improvements. We used BrdU and YFP to label and track neural stem cells and a neural stem cell-specific Sox9 knockout mouse model …
Testing The Template Hypothesis Of Vocal Learning In Songbirds., Adriana Diez
Testing The Template Hypothesis Of Vocal Learning In Songbirds., Adriana Diez
Electronic Thesis and Dissertation Repository
The auditory forebrain regions NCM and CMM of songbirds are associated with perception and complex auditory processing. Expression of the immediate-early gene ZENK varies in response to different sounds. Two hypotheses are proposed for this. First, ZENK may reflect access to a representation of song memories. Second, ZENK may reflect attention. I tested these hypotheses by measuring ZENK in response to tutored heterospecific or isolate songs compared to non-tutored wild-type song. Young zebra finch females were exposed to different tutoring conditions and later exposed to different playbacks, and the expression of ZENK in CMM and NCM measured. ZENK responses varied …
Dopamine Modulation Of Emotional Learning In The Medial Prefrontal Cortex, Nicole M. Lauzon
Dopamine Modulation Of Emotional Learning In The Medial Prefrontal Cortex, Nicole M. Lauzon
Electronic Thesis and Dissertation Repository
Dopamine (DA) transmission plays a critical role in the processing of emotionally salient information and in associative learning and memory processes. Within the mammalian brain, neurons within the medial prefrontal cortex (mPFC) are involved critically in the encoding, expression, and extinction of emotionally salient learned information. Within the mPFC, DAergic transmission is involved importantly in controlling attention related and motivational processes, particularly within the context of emotionally salient sensory information. Considerable evidence suggests differential roles for DA D1-like versus D2-like receptors, including the D4-receptor subtype, in the regulation of neuronal activity and emotional processing …
Amyloid Beta Resistance And The Warburg Effect: Re-Examining Alzheimer's Disease, Jordan Taylor Newington
Amyloid Beta Resistance And The Warburg Effect: Re-Examining Alzheimer's Disease, Jordan Taylor Newington
Electronic Thesis and Dissertation Repository
Alzheimer’s disease (AD) is characterized by deposition of the amyloid beta (Ab) peptide in the brain, an event which frequently but not universally correlates with nerve cell death. Although most nerve cells die in response to Ab, small populations of cells are able to survive by becoming resistant to Ab toxicity. Understanding the mechanisms by which cells become resistant to Ab may reveal novel treatments for AD. Interestingly, nerve cell lines selected for resistance against Ab exhibit increased glucose uptake and glycolytic flux. Here I show that these metabolic changes are mediated through an upregulation of pyruvate dehydrogenase kinase 1 …
Circadian Rhythms In Reward And Underlying Neural Circuits, Ricardo M. Baltazar
Circadian Rhythms In Reward And Underlying Neural Circuits, Ricardo M. Baltazar
Electronic Thesis and Dissertation Repository
Studies suggest that the circadian timing system exerts an important influence on responses to rewarding stimuli. Diurnal rhythms in the rewarding value of amphetamine and mating behavior were observed, but differed in the pattern of their timing. Daily fluctuations in reward were correlated with oscillations in mesolimbic dopaminergic activity in both the nucleus accumbens (NAc) and ventral tegmental area (VTA), with a peak in NAc coinciding with the peak of sex reward, while the peak in the VTA associated with the peak in amphetamine reward. Also, rhythmic expression of the marker of neural activation, cFos, was observed in NAc, medial …