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Identification Of Deletion Mutants Of Inositol Kinases And Phosphatases Hypersensitive To Valproate, W-Mudiyanselage Manoj Senaka Bandara
Identification Of Deletion Mutants Of Inositol Kinases And Phosphatases Hypersensitive To Valproate, W-Mudiyanselage Manoj Senaka Bandara
Wayne State University Theses
ABSTRACT
IDENTIFICATION OF DELETION MUTANTS OF INOSITOL KINASES AND PHOSPHATASES HYPERSENSITIVE TO VALPROATE
by
WELLEWATTA MUDIYANSELAGE MANOJ SENAKA BANDARA
MAY 2010
Advisor: Dr. Miriam Greenberg
Major: Biological Sciences
Degree: Master of Science
Bipolar disorder (BD) is a chronic psychiatric illness affecting at least 1% of the world population. BD is ranked as the sixth greatest cause of death or disability globally. The cause of BD is unknown. Although the anticonvulsant valproate (VPA) is widely used as a mood stabilizer to treat BD, VPA is not completely effective and causes numerous side effects. Hence, it is important to develop more effective …