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Implications Of The Calm-Af10 Oncogenic Fusion Protein On Wnt Signaling In Leukemia, Jamie Lucille Deutsch
Implications Of The Calm-Af10 Oncogenic Fusion Protein On Wnt Signaling In Leukemia, Jamie Lucille Deutsch
Graduate College Dissertations and Theses
Hematopoiesis is the complex differentiation process involving the formation of all blood cells from a common progenitor; the hematopoietic stem cell. Errors in this process can lead to acute leukemia, or a rapid accumulation of immature blood cells which hinders proper immune function. While survival rates of this devastating disease have increased dramatically over the last several decades, certain cytogenetic abnormalities remain risk factors for treatment resistance and relapse. One of these abnormalities is a chromosomal translocation involving the transcription factor, AF10
Mix-Lineage Leukemia, Translocated to, 10 (MLLT 10, referred to as AF10) is involved in several oncogenic translocations involved …