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The Effect Of Ultraviolet Light On Cell Viability, Dna Damage And Repair In Hutchinson-Gilford Progeria Syndrome And Bj Fibroblasts., Mckayla Johnson
The Effect Of Ultraviolet Light On Cell Viability, Dna Damage And Repair In Hutchinson-Gilford Progeria Syndrome And Bj Fibroblasts., Mckayla Johnson
Undergraduate Honors Theses
Patients of Hutchinson-Gilford Progeria Syndrome (HGPS) display a rate of aging up to ten times that of normal human populations. It might be expected that HGPS cells would have a decreased ability to repair DNA damage through the cell cycle as compared to normal cells such as those of the BJ cell line since DNA damage accumulation is a hallmark phenotype of aging. On earth, we are exposed to far more ultraviolet-B (UV-B, 280-315 nm) and UV-A (315-400 nm) than UV-C (100-280 nm) radiation, since the latter is filtered-out by the atmospheric ozone layer. The relative sensitivity of prematurely aging …