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Full-Text Articles in Life Sciences
Dietary L-Tryptophan Consumption Determines The Number Of Colonic Regulatory T Cells And Susceptibility To Colitis Via Gpr15, Nguyen Van, Karen Zhang, Rachel Wigmore, Anne Kennedy, Carolina Dasilva, Jialing Huang, Manju Ambelil, Jose Villagomez, Gerald O'Connor, Randy Longman, Miao Cao, Adam Snook, Michael Platten, Gerard Kasenty, Luis Sigal, George C Prendergast, Sangwon Kim
Dietary L-Tryptophan Consumption Determines The Number Of Colonic Regulatory T Cells And Susceptibility To Colitis Via Gpr15, Nguyen Van, Karen Zhang, Rachel Wigmore, Anne Kennedy, Carolina Dasilva, Jialing Huang, Manju Ambelil, Jose Villagomez, Gerald O'Connor, Randy Longman, Miao Cao, Adam Snook, Michael Platten, Gerard Kasenty, Luis Sigal, George C Prendergast, Sangwon Kim
Department of Microbiology and Immunology Faculty Papers
Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription level of the colonic T cell homing receptor, GPR15, hence affecting the number of colonic FOXP3+ regulatory T (Treg) cells and local immune homeostasis. Ingested L-Trp is converted by host IDO1/2 enzymes, but not by gut microbiota, to compounds that induce GPR15 transcription preferentially in Treg cells via the aryl hydrocarbon receptor. Consequently, two weeks of dietary L-Trp supplementation nearly double …
Crimean-Congo Hemorrhagic Fever: A Tick-Borne Killer, Deisy Reyes Andrade, Sofia Dodge, Basheer Alam
Crimean-Congo Hemorrhagic Fever: A Tick-Borne Killer, Deisy Reyes Andrade, Sofia Dodge, Basheer Alam
Research and Scholarship Symposium Posters
Crimean-Congo Hemorrhagic Fever (CCHF) is a tick-borne virus. It was first identified in Crimea in 1944 and was later detected in Congo in 1969. It is endemic where it is mainly located in regions such as Africa, Europe, and Asia. CCHF is primarily transmitted through the bite of an infected tick, however direct contact with bodily fluids can also be another route of transmission. Specifically, Hyalomma ticks are the main reservoirs and vectors of CCHF. Symptoms may range from asymptomatic to severe development of hemorrhage, with a fatality rate of up to 40%. Initial symptoms include headaches, high fevers, body …