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Functional And Genetic Characterization Of Sulfatases In Salmonella Enterica Serovar Typhimurium, Seema Das
Functional And Genetic Characterization Of Sulfatases In Salmonella Enterica Serovar Typhimurium, Seema Das
Theses and Dissertations
Salmonella enterica serovar Typhimurium is a gram-negative facultative intracellular food borne pathogen and accounts for $365 million in direct medical costs annually. The ability of S. Typhimurium to compete with the other microorganisms in the host gastrointestinal tract for nutrients and penetrate the epithelial mucosal layers is essential for its pathogenesis. The host mucosal glycans, the potential source of carbohydrates for gut microbiota, are heavily sulfated, making them resistant to digestion. The ability to produce sulfatases is important for utilizing the host-derived carbohydrates, intestinal adhesion, invasion of the host epithelium and systemic infection. The genomes of many enteric human pathogens …
Investigating The Persistence And "Naturalization" Potential Of Salmonella In Non-Host Environments Using Culture-Based And Molecular-Based Fingerprinting Techniques, Robyn L. Morrison
Investigating The Persistence And "Naturalization" Potential Of Salmonella In Non-Host Environments Using Culture-Based And Molecular-Based Fingerprinting Techniques, Robyn L. Morrison
Theses and Dissertations (Comprehensive)
Recent studies suggest the potential exists for enteric microorganisms to become “naturalized” to the complex natural environment through maintenance of their populations via replication and adaptation to the stress imposed by their external surroundings. The aim of this research was to better understand the potential for antimicrobial resistant (AMR) Salmonella to become “naturalized” and the physiological adaptations that allow for non-host survivability as reflected by AMR and community profiling. To better elucidate the prominent factors leading to a “naturalized” condition, two approaches were taken: 1) survey-based field research to gain perspective on the prevalence of AMR Salmonella isolated from variously …