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Full-Text Articles in Life Sciences
Aminoglycosides And Syringomycin E As Fungicides Against Fusarium Graminearum In Head Blight Disease, Yukie Kawasaki
Aminoglycosides And Syringomycin E As Fungicides Against Fusarium Graminearum In Head Blight Disease, Yukie Kawasaki
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Fusarium graminearum is one of the most problematic phytopathogens in US agriculture. This fungus causes head blight, foot rot, and damping off on wheat and barley. The infection lowers the grain yield and causes contamination of the grain product with mycotoxins. Effective control measures are lacking, and new fungicides that kill F. graminearum but remain safe and economical to use are needed. Newly synthesized aminoglycosides (JL22, JL38, JL39, JL40, NEOF004, NEOF005), classic aminoglycosides (amikacin, gentamicin, kanamycin A, kanamycin B, neomycin, and ribostamycin), and a lipopeptide, syringomycin E (SRE), were studied to determine their antifungal potential to control F. graminearum. …
Dechlorinating And Iron Reducing Bacteria Distribution In A Trichloroethene Contaminated Aquifer, Carmen Lourdes Yupanqui Zaa
Dechlorinating And Iron Reducing Bacteria Distribution In A Trichloroethene Contaminated Aquifer, Carmen Lourdes Yupanqui Zaa
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The Operable Unit 5 (OU 5) area of Hill Air Force Base currently has two trichloroethene-contaminated groundwater plumes underneath residential areas in Sunset and Clinton, Utah. Bioremediation by biological reductive dechlorination can be an important mechanism for the removal of chlorinated compounds from the plumes. The presence of suitable bacteria to carry on reductive dechlorination is the key in the bioremediation process. The goal of this study was to determine the distribution and population density of the 16S rRNA genes of Bacteria, Dehalococcoides ethenogenes, Desulfuromonas michiganensis, Geobacter spp and Rhodoferax ferrireducens-like bacteria, as well as the functional genes trichloroethene reductive …
Treatment Of Late Stage Disease In A Model Of Arenaviral Hemorrhagic Fever: T-705 Efficacy And Reduced Toxicity Suggests An Alternative To Ribavirin, B B. Gowen, D F. Smee, M H. Wong, J O. Hall, K H. Jung, K W. Bailey, J R. Stevens, Y Furuta, John D. Morrey
Treatment Of Late Stage Disease In A Model Of Arenaviral Hemorrhagic Fever: T-705 Efficacy And Reduced Toxicity Suggests An Alternative To Ribavirin, B B. Gowen, D F. Smee, M H. Wong, J O. Hall, K H. Jung, K W. Bailey, J R. Stevens, Y Furuta, John D. Morrey
John D. Morrey
A growing number of arenaviruses are known to cause viral hemorrhagic fever (HF), a severe and life-threatening syndrome characterized by fever, malaise, and increased vascular permeability. Ribavirin, the only licensed antiviral indicated for the treatment of certain arenaviral HFs, has had mixed success and significant toxicity. Since severe arenaviral infections initially do not present with distinguishing symptoms and are difficult to clinically diagnose at early stages, it is of utmost importance to identify antiviral therapies effective at later stages of infection. We have previously reported that T-705, a substituted pyrazine derivative currently under development as an anti-influenza drug, is highly …