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Full-Text Articles in Life Sciences

Topical Lipophilic Epigallocatechin-3-Gallate On Herpes Labialis: A Phase Ii Clinical Trial Of Averteax Formula, Man Zhao, Rong Zheng, Jinyan Jiang, Douglas Dickinson, Baiping Fu, Tin-Chun Chu, Lee Lee, Hanna Pearl, Stephen Hsu Sep 2015

Topical Lipophilic Epigallocatechin-3-Gallate On Herpes Labialis: A Phase Ii Clinical Trial Of Averteax Formula, Man Zhao, Rong Zheng, Jinyan Jiang, Douglas Dickinson, Baiping Fu, Tin-Chun Chu, Lee Lee, Hanna Pearl, Stephen Hsu

Tin-Chun Chu, Ph.D.

Objectives The aim of this study was to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX) on recurrent herpes labialis. Methods A double blind, placebo-controlled, randomized trial with 40 participants initially in two groups. Results Compared to the vehicle group, AverTeaX applied topically 6-8 times daily resulted in a significant reduction of clinical episode duration (median 4.5 days, range 1-11 days vs. 9 days, range 2-11 days, p=0.003) and shortened blistering/ulceration stages within an episode from a median of 3 (range 0-6) days to 1 (range 0-3) day (p=0.0003). Median quality of life scores based on a multi-question …


Antiviral Activity Of Theaflavin Digallate Against Herpes Simplex Virus Type 1, Aline De Oliveira, Derek Prince, Chih-Yu Lo, Lee Lee, Tin-Chun Chu May 2015

Antiviral Activity Of Theaflavin Digallate Against Herpes Simplex Virus Type 1, Aline De Oliveira, Derek Prince, Chih-Yu Lo, Lee Lee, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

Tea is the second most consumed drink in the world. The beneficial effects of tea have been mostly attributed to its catechin content. Black tea is derived from the leaves of Camellia sinensis plant, and it is rich in theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3′-monogallate (TF2B), and theaflavin-3,3′-digallate (TF3). Vero and A549 cells were used to evaluate the effect of purified individual black tea theaflavins as anti-herpes simplex virus 1 agents. With the rise of HSV resistant strains, there is a critical need to develop novel antiherpesviral treatments. Results of the cytotoxicity assay tested by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxy-phenyl)-2-(4-sulfophenyl)-2H-tetrazolium] …


Bioinformatics Analyses Of Chromium Tolerant Genes In Cyanobacteria And Identification Of Their Operon In Synechococcus Sp. Iu 625, Lee Lee, Richard Garrett, Anna Slusarczyk, Jose Perez, Tin-Chun Chu Jul 2013

Bioinformatics Analyses Of Chromium Tolerant Genes In Cyanobacteria And Identification Of Their Operon In Synechococcus Sp. Iu 625, Lee Lee, Richard Garrett, Anna Slusarczyk, Jose Perez, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Bloom-Forming Cyanobacteria And Other Phytoplankton In Northern New Jersey Freshwater Bodies, Tin-Chun Chu, Matthew Rienzo Jan 2013

Bloom-Forming Cyanobacteria And Other Phytoplankton In Northern New Jersey Freshwater Bodies, Tin-Chun Chu, Matthew Rienzo

Tin-Chun Chu, Ph.D.

No abstract provided.


Inhibition Of Herpes Simplex Virus Type 1 With The Modified Green Tea Polyphenol Pamitoyl-Epigallocatechin Gallate., Aline De Oliveira, Sandra Adams, Lee Lee, Sean Murray, Stephen Hsu, Jeffrey Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu Oct 2012

Inhibition Of Herpes Simplex Virus Type 1 With The Modified Green Tea Polyphenol Pamitoyl-Epigallocatechin Gallate., Aline De Oliveira, Sandra Adams, Lee Lee, Sean Murray, Stephen Hsu, Jeffrey Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Epigallocatechin-3-Gallate Modulates Oxidative Stress In Exocrine Glands Of A Primary Sjogren’S Syndrome Mouse Model Prior To Disease Onset, Seiji Ohno, Hongfang Yu, Douglas Dickinson, Tin-Chun Chu, Kalu Ogbureke, Scott Derossi, Tetsuya Yamamoto, Stephen Hsu Oct 2012

Epigallocatechin-3-Gallate Modulates Oxidative Stress In Exocrine Glands Of A Primary Sjogren’S Syndrome Mouse Model Prior To Disease Onset, Seiji Ohno, Hongfang Yu, Douglas Dickinson, Tin-Chun Chu, Kalu Ogbureke, Scott Derossi, Tetsuya Yamamoto, Stephen Hsu

Tin-Chun Chu, Ph.D.

No abstract provided.


Protamine-Like Proteins In 12 Sequenced Species Of Drosophila, Zain Alvi, Tin-Chun Chu, Valerie Schawaroch, Angela Klaus Jul 2012

Protamine-Like Proteins In 12 Sequenced Species Of Drosophila, Zain Alvi, Tin-Chun Chu, Valerie Schawaroch, Angela Klaus

Tin-Chun Chu, Ph.D.

No abstract provided.


Identification And Bioinformatic Analyses Of Vanillate Operon In Cyanobacterium Synechococcus Sp. Iu 625, Robert Newby, Tin-Chun Chu Jun 2012

Identification And Bioinformatic Analyses Of Vanillate Operon In Cyanobacterium Synechococcus Sp. Iu 625, Robert Newby, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Bioinformatic Analysis Of Cyanobacterial Mercuric Resistance Genes And Identification Of Synechococcus Sp. Iu 625 Putative Mercuric Resistance Genes, Lee Lee, Chiedozie Okafor, Matthew Rienzo, Tin-Chun Chu Jun 2012

Bioinformatic Analysis Of Cyanobacterial Mercuric Resistance Genes And Identification Of Synechococcus Sp. Iu 625 Putative Mercuric Resistance Genes, Lee Lee, Chiedozie Okafor, Matthew Rienzo, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Adaption Of Synechococcus Sp. Iu 625 To Growth In The Presence Of Mercuric Chloride, Tin-Chun Chu, Sean Murray, Jennifer Todd, Winder Perez, Jonathan Yarborough, Chiedozie Okafor, Lee Lee Dec 2011

Adaption Of Synechococcus Sp. Iu 625 To Growth In The Presence Of Mercuric Chloride, Tin-Chun Chu, Sean Murray, Jennifer Todd, Winder Perez, Jonathan Yarborough, Chiedozie Okafor, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Temperature-Induced Activation Of Freshwater Cyanophage As-1 Prophage., Tin-Chun Chu, Sean Murray, Shi-Fang Hsu, Quinn Vega, Lee Lee Apr 2011

Temperature-Induced Activation Of Freshwater Cyanophage As-1 Prophage., Tin-Chun Chu, Sean Murray, Shi-Fang Hsu, Quinn Vega, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Molecular Probes For The Detection Of Cyanophage As-1 And Its Cyanobacterial Hosts., Tin-Chun Chu, Jonathan Jimenez, Lauren Strawn, Michelle Reed, Lauren Pohren, Lee Lee Jun 2010

Molecular Probes For The Detection Of Cyanophage As-1 And Its Cyanobacterial Hosts., Tin-Chun Chu, Jonathan Jimenez, Lauren Strawn, Michelle Reed, Lauren Pohren, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee Jun 2009

Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Effects Of Oral Consumption Of The Green Tea Polyphenol Egcg In A Murine Model For Human Sjogren's Syndrome, An Autoimmune Disease., K. Gillespie, I. Kodani, D. Dickinson, K. Ogbureke, A. Camba, M. Wu, S. Looney, Tin-Chun Chu, H. Qin, F. Bisch, M. Sharawy, G. Schuster, S. Hsu Sep 2008

Effects Of Oral Consumption Of The Green Tea Polyphenol Egcg In A Murine Model For Human Sjogren's Syndrome, An Autoimmune Disease., K. Gillespie, I. Kodani, D. Dickinson, K. Ogbureke, A. Camba, M. Wu, S. Looney, Tin-Chun Chu, H. Qin, F. Bisch, M. Sharawy, G. Schuster, S. Hsu

Tin-Chun Chu, Ph.D.

No abstract provided.


Microbiology Laboratory Manual, Lee Lee, Tin-Chun Chu Dec 2007

Microbiology Laboratory Manual, Lee Lee, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Identification Of Synechococcus Sp. Iu 625 Metallothionein Gene And Its Evolutionary Relationship To The Metallothionein Gene Of Other Cyanobacteria, Tin-Chun Chu, Lee Lee, John Gaynor, Quinn Vega, Bonnie Lustigman, Shankar Srinivasan Jun 2007

Identification Of Synechococcus Sp. Iu 625 Metallothionein Gene And Its Evolutionary Relationship To The Metallothionein Gene Of Other Cyanobacteria, Tin-Chun Chu, Lee Lee, John Gaynor, Quinn Vega, Bonnie Lustigman, Shankar Srinivasan

Tin-Chun Chu, Ph.D.

No abstract provided.


Induction Of Temperate Cyanophage As-1 By Heavy Metal - Copper, Lee Lee, Lui Doris, Patricia Platner, Shi-Fang Hsu, Tin-Chun Chu, John Gaynor, Quinn Vega, Bonnie Lustigman Jan 2006

Induction Of Temperate Cyanophage As-1 By Heavy Metal - Copper, Lee Lee, Lui Doris, Patricia Platner, Shi-Fang Hsu, Tin-Chun Chu, John Gaynor, Quinn Vega, Bonnie Lustigman

Tin-Chun Chu, Ph.D.

No abstract provided.


Cgkb-Cyanogroup Genomics Knowledge Base, Tin-Chun Chu, Lee Lee, Shankar Srinivasan, John Gaynor, Quinn Vega, Bonnie Lustigman May 2005

Cgkb-Cyanogroup Genomics Knowledge Base, Tin-Chun Chu, Lee Lee, Shankar Srinivasan, John Gaynor, Quinn Vega, Bonnie Lustigman

Tin-Chun Chu, Ph.D.

No abstract provided.


Effect Of Cadmium On The Growth Of Chlamydomonas, Suzen Awad, Tin-Chun Chu, Bonnie Lustigman, Lee Lee Mar 2005

Effect Of Cadmium On The Growth Of Chlamydomonas, Suzen Awad, Tin-Chun Chu, Bonnie Lustigman, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Bioinformatic Analysis Of The Metal-Binding Protein Families And Heavy Metal Resistance Amongst Cyanobacteria, Tin-Chun Chu, Lee Lee, Shankar Srinivasan Dec 2004

Bioinformatic Analysis Of The Metal-Binding Protein Families And Heavy Metal Resistance Amongst Cyanobacteria, Tin-Chun Chu, Lee Lee, Shankar Srinivasan

Tin-Chun Chu, Ph.D.

No abstract provided.