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Towards Better Detection And Treatment Of Mycobacterial Disease., Laura O'Connell
Towards Better Detection And Treatment Of Mycobacterial Disease., Laura O'Connell
ORBioM (Open Research BioSciences Meeting)
Background
Mycobacterial disease is a major cause of fatality, with 1.5 million deaths per 10 million infections annually. Due to the emergence of multi- and extensively-drug resistant clinical isolates, mycobacteriophage (MP) are being investigated as an alternative to antibiotics.
Objectives
The objectives of this study were: to characterise an emerging cohort of MP, to determine suitable in vivo modes of delivery for MP including encapsulation, to examine the application of a MP-based viability assay, and to examine the functionality of MP in raw milk.
Methods
The fast-growing Mycobacterium smegmatis was used as a host in all assays to demonstrate phage …