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Functional And Genetic Characterization Of Sulfatases In Salmonella Enterica Serovar Typhimurium, Seema Das

Theses and Dissertations

Salmonella enterica serovar Typhimurium is a gram-negative facultative intracellular food borne pathogen and accounts for $365 million in direct medical costs annually. The ability of S. Typhimurium to compete with the other microorganisms in the host gastrointestinal tract for nutrients and penetrate the epithelial mucosal layers is essential for its pathogenesis. The host mucosal glycans, the potential source of carbohydrates for gut microbiota, are heavily sulfated, making them resistant to digestion. The ability to produce sulfatases is important for utilizing the host-derived carbohydrates, intestinal adhesion, invasion of the host epithelium and systemic infection. The genomes of many enteric human pathogens …