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Full-Text Articles in Life Sciences
Peripheral Dendritic Cells Are Essential For Both The Innate And Adaptive Antiviral Immune Responses In The Central Nervous System, Christina D. Steel, Suzanna M. Hahto, Richard P. Ciavarra
Peripheral Dendritic Cells Are Essential For Both The Innate And Adaptive Antiviral Immune Responses In The Central Nervous System, Christina D. Steel, Suzanna M. Hahto, Richard P. Ciavarra
Biological Sciences Faculty Publications
Intranasal application of vesicular stomatitis virus (VSV) causes acute infection of the central nervous system (CNS). However, VSV encephalitis is not invariably fatal, suggesting that the CNS may contain a professional antigen-presenting cell (APC) capable of inducing or propagating a protective antiviral immune response. To examine this possibility, we first characterized the cellular elements that infiltrate the brain as well as the activation status of resident microglia in the brains of normal and transgenic mice acutely ablated of peripheral dendritic cells (DCs) in vivo. VSV encephalitis was characterized by a pronounced infiltrate of myeloid cells (CD45highCD11b+ …
Results From A Mathematical Model For Human Monocytic Ehrlichiosis, H. Gaff, L. Gross, E. Schaefer
Results From A Mathematical Model For Human Monocytic Ehrlichiosis, H. Gaff, L. Gross, E. Schaefer
Biological Sciences Faculty Publications
Human monocytic ehrlichiosis (Ehrlichia chaffeensis), HME, is a tick-transmitted, rickettsial disease that has recently increased substantially in the USA from 142 reported cases in 2001 to 506 reported cases in 2005 [1,2]. There have been increasing surveys of tick populations over the past 10 years that have in turn supported the development of models for tick-borne disease transmission. Resulting HME models [3] suggest the importance of metapopulation structures, landscape environment parameters and periodic climatic effects in predicting the dynamics of HME transmission and the efficacy of control efforts, such as the reduction of the tick population through acaricide …