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Neutrophil Subtype Differentiation In Campylobacter Jejuni Infection And Its Impact On T Cells And Colonic Epithelial Cells, Carolina Dolislager
Neutrophil Subtype Differentiation In Campylobacter Jejuni Infection And Its Impact On T Cells And Colonic Epithelial Cells, Carolina Dolislager
Masters Theses
The discovery of neutrophil subtypes has expanded what is known about neutrophil functions, yet there is still much to learn about the role of these subtypes during bacterial infection. We investigated whether Campylobacter jejuniinduced differentiation of human neutrophils into the hypersegmented, CD16hi/CD62Llo[CD16hi/CD62Llo] subtype. In addition, we investigated whether C. jejuni-dependent differentiation of this neutrophil subtype induced cancer promoting activities ofhuman T cells and colonocytes, whichwere observed in other studies of hypersegmented, CD16hi/CD62Llo[CD16hi/CD62Llo] neutrophils. We found that C. jejunicauses a significant shift in human neutrophil populations to the hypersegmented, CD16 …