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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Evidence Of An Infectious Asthma Phenotype: Chlamydia Driven Allergy And Airway Hyperresponsiveness In Pediatric Asthma, Katir Kirit Patel
Evidence Of An Infectious Asthma Phenotype: Chlamydia Driven Allergy And Airway Hyperresponsiveness In Pediatric Asthma, Katir Kirit Patel
Open Access Dissertations
Asthma is the most common chronic respiratory disease affecting young children and adults all over the world. An estimated 34.1 million Americans have reported asthma in their lifetime and the disease costs ~US $56 billion dollars to treat each year. Current treatment is based on a paradigm of asthma as a non-infectious atopic condition whose root cause is inflammation. Chronically administered anti-inflammatory medications, primarily inhaled corticosteroids (ICS), ameliorate asthma symptoms in many patients. However, up to 50% of asthmatics, characterized by neutrophil infiltration, IL-17 secretion and increased risk of fatality are refractory to ICS treatment. Chlamydia pneumoniae, a ubiquitous, obligate …
Reca Dynamics & The Sos Response In Escherichia Coli: Cellular Limitation Of Inducing Filaments, Shawn Christopher Massoni
Reca Dynamics & The Sos Response In Escherichia Coli: Cellular Limitation Of Inducing Filaments, Shawn Christopher Massoni
Open Access Dissertations
During the course of normal DNA replication, replication forks are constantly encountering "housekeeping" types of routine damage to the DNA template that may cause the forks to stall or collapse. One product of this fork collapse is the induction of the SOS response, a coordinated global response to help pause the growth and replication of a cell while DNA damage is addressed and repaired. In E. coli, this response is activated by the formation of ssDNA, to which the RecA protein binds and forms a nucleoprotein filament, which acts as the activator for autocleavage of the LexA transcriptional repressor, which …
Investigation Of A Sulfur-Utilizing Perchlorate-Reducing Bacterial Consortium, Teresa Anne Conneely
Investigation Of A Sulfur-Utilizing Perchlorate-Reducing Bacterial Consortium, Teresa Anne Conneely
Open Access Dissertations
We present research investigating how, with in depth knowledge of the community, microbial communities may be harnessed for bioremediation of hazardous water contaminants. We focused on the bacterial reduction of perchlorate, a common water contaminant. For this we studied the structure and capabilities of a novel sulfur-utilizing, perchlorate-reducing bacterial (SUPeRB) consortium. Initially, we characterized the minimal consortium that retained functional capabilities, using 16S rRNA and functional gene analysis. A diverse functional consortium dominated by Beta-Proteobacteria of the family Rhodocyclaceae and sulfur-oxidizing Epsilon-Proteobacteria was found. We also examined the optimal growth conditions under which perchlorate degradation occurred and uncovered the upper …
Mitochondrial Dna Polymerase Ib: Functional Characterization Of A Putative Drug Target For African Sleeping Sickness, David F. Bruhn
Mitochondrial Dna Polymerase Ib: Functional Characterization Of A Putative Drug Target For African Sleeping Sickness, David F. Bruhn
Open Access Dissertations
Trypanosoma brucei and related parasites are causative agents of severe diseases that affect global health and economy. T. brucei is responsible for sleeping sickness in humans (African trypanosomiasis) and a wasting disease in livestock. More than 100 years after T. brucei was identified as the etiological agent for sleeping sickness, available treatments remain inadequate, complicated by toxicity, lengthy and expensive administration regiments, and drug-resistance. There is clear need for the development of a new antitrypanosomal drugs. Due to the unique evolutionary position of these early diverging eukaryotes, trypanosomes posses a number of biological properties unparalleled in other organisms, including humans, …
Growth Kinetics And Constraints Related To Metabolic Diversity And Abundances Of Hyperthermophiles In Deep-Sea Hydrothermal Vents, Helene Chavanne Ver Eecke
Growth Kinetics And Constraints Related To Metabolic Diversity And Abundances Of Hyperthermophiles In Deep-Sea Hydrothermal Vents, Helene Chavanne Ver Eecke
Open Access Dissertations
This dissertation research aims to show that there are deterministic microbial distribution patterns based on quantifiable environmental thresholds by determining and rationalizing the relative abundances of hyperthermophilic methanogens, autotrophic iron(III) oxide reducers, and heterotrophic sulfur reducers within deep-sea hydrothermal vents. Organisms of these metabolisms are predicted to be relatively more abundant in different regions depending on environmental conditions such as reduction potential, organic carbon, and hydrogen availability. The relative abundances of these metabolic groups within samples from the Endeavour Segment and Axial Volcano in the northeastern Pacific Ocean were determined. Iron(III) oxide reducers were detected in nearly all samples while …
Role Of Sulfate-Reducing Bacteria In The Attenuation Of Acid Mine Drainage Through Sulfate And Iron Reduction, Caryl Ann Becerra
Role Of Sulfate-Reducing Bacteria In The Attenuation Of Acid Mine Drainage Through Sulfate And Iron Reduction, Caryl Ann Becerra
Open Access Dissertations
Acid mine drainage (AMD) is an acidic, iron-rich leachate that causes the dissolution of metals. It constitutes a worldwide problem of environmental contamination detrimental to aquatic life and water quality. AMD, however, is naturally attenuated at Davis Mine in Rowe, Massachusetts. We hypothesize that sulfate-reducing bacteria (SRB) are attenuating AMD. To elucidate the mechanisms by which SRB attenuate AMD, three research projects were conducted using a suite of molecular and geochemical techniques. First we established biological influence on the attenuation of AMD by comparing the microbial community and geochemical trends of microcosms of two contrasting areas within the site: AMD …
Investigation Of Chemotaxis Genes And Their Functions In Geobacter Species, Hoa T. Tran
Investigation Of Chemotaxis Genes And Their Functions In Geobacter Species, Hoa T. Tran
Open Access Dissertations
Geobacter species are δ-Proteobacteria and are often predominant in the Fe(III) reduction zone of sedimentary environments. Their abilities to remediate contaminated environments and to produce electricity have inspired extensive studies. Cell motility, biofilm formation, and type IV pili, which have been shown to be regulated by chemotaxis genes in other bacteria, all appear important for the growth of Geobacter species in changing environments and for electricity production. The genomes of Geobacter species show the presence of a significant number of chemotaxis gene homologs, suggesting important roles for them in the physiology of Geobacter species, although gene functions are not yet …