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Full-Text Articles in Life Sciences
Msab And Cody Interact To Regulate Staphylococcus Aureus Capsule In A Nutrient-Dependent Manner, Justin Batte, Gyan S. Sahukhal, Mohamed O. Elasri
Msab And Cody Interact To Regulate Staphylococcus Aureus Capsule In A Nutrient-Dependent Manner, Justin Batte, Gyan S. Sahukhal, Mohamed O. Elasri
Faculty Publications
Staphylococcus aureus has a complex regulatory network for controlling the production of capsule polysaccharide. In S. aureus, capsule production is controlled by several regulators in response to various environmental stimuli. Previously, we described MsaB as a new regulator that specifically binds to the cap promoter in a growth-phase or nutrient-dependent manner. In addition to MsaB, several other regulators have also been shown to bind the same region. In this study, we examined the interactions between MsaB and other nutrient-sensing regulators (CodY and CcpE) with respect to binding to the cap promoter in a nutrient-dependent manner. We observed that msaABCR …
The Regulatory Relationship Of Transcriptional Regulators Msab And Cody In Capsule Production In Staphylococcus Aureus, Brittany L. Trunell
The Regulatory Relationship Of Transcriptional Regulators Msab And Cody In Capsule Production In Staphylococcus Aureus, Brittany L. Trunell
Honors Theses
There are many transcriptional regulators found in pathogenic Staphylococcus aureus. Many of these regulators are essential for the organism’s ability to switch from commensal form to the virulent pathogenic form. One of these main regulators is CodY. This regulator has been shown to be responsive to nutrient availability during phases of growth. Additionally, we have recently found that MsaB, the only protein coding ORF of the msaABCR operon, is a putative co-regulator of capsule along with CodY. To explore these regulator interactions, we produced mutations of codY and msaABCR individually and a double mutation of msaABCR/ codY. We have observed …