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Development Of A Non-Invasive Liquid Biopsy For Detection Of Cmvil-10, Alexander Shin, Margarette Mariano, Juliet Spencer
Development Of A Non-Invasive Liquid Biopsy For Detection Of Cmvil-10, Alexander Shin, Margarette Mariano, Juliet Spencer
Creative Activity and Research Day - CARD
Human cytomegalovirus (HCMV) is a prevalent type of herpes virus in our population. HCMV infection has no effect on the majority of people, but in some cases HCMV is strongly correlated with various medical outcomes, such as breast cancer. We focus on the UL111A gene product of HCMV, which encodes the secreted protein cmvIL-10. CmvIL-10 is a homolog of human cytokine IL-10 (hIL-10), which has immunosuppressive effects and promotes proliferation and invasion of breast cancer cells in vitro. We are measuring cmvIL-10 in human blood and have found elevated levels of cmvIL-10 in cancer patients. Here, we are investigating the …