Life Sciences Commons^™

Innate Immune Recognition Of Candida Albicans In Zebrafish, Monique Elaine Theriault

Honors College

Candida albicans is an opportunistic fungal pathogen that has the capability to switch from commensal to pathogen in immunocompromised individuals. Recognition of pathogens, like C. albicans, during infection is poorly characterized primarily due to the difficulties in visualizing the host/pathogen interaction without killing the host. Transparent animal hosts, such as Danio rerio (zebrafish), enable imaging of pathogen recognition while maintaining host viability. For pathogen recognition, zebrafish likely use immune receptors similar to mammalian receptors including C-type lectin receptors. Human C-type lectin receptors have already been shown to be crucial in recognition of fungal pathogens like C. albicans, and our goal …