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The Abundance Of Akkermansia Muciniphila And Its Relationship With Sulphated Colonic Mucins In Health And Ulcerative Colitis, Helen Earley, Grainne Earley, Aine Balfe, J. Calvin Coffey, Desmond C. Winter, Ronan O'Connell
The Abundance Of Akkermansia Muciniphila And Its Relationship With Sulphated Colonic Mucins In Health And Ulcerative Colitis, Helen Earley, Grainne Earley, Aine Balfe, J. Calvin Coffey, Desmond C. Winter, Ronan O'Connell
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Akkermansia muciniphila utilises colonic mucin as its substrate. Abundance is reduced in ulcerative colitis (UC), as is the relative proportion of sulphated mucin in the mucus gel layer (MGL). It is unknown if these phenomena are related, however reduced sulphated mucins could contribute to reduced abundance, owing to a lack of substrate. The aim of this study was to quantify A. muciniphila within the MGL and to relate these findings with markers of inflammation and the relative proportion of sulphomucin present. Colonic biopsies and mucus brushings were obtained from 20 patients with active UC (AC), 14 with quiescent UC (QUC) …