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Antimicrobial Action Of 1,10-Phenanthroline-Based Compoundson Carbapenemase-Producing Acinetobacter Baumannii Clinical Strains: Efficacy Against Planktonic- And Biofilm-Growing Cells, Roberta F. Ventura, Anna Clara M. Galdino, Livia Viganor, Ricardo P. Schuenck, Michael Devereux, Malachy Mccann, André L.S. Santos, Ana Paula F. Nunes
Antimicrobial Action Of 1,10-Phenanthroline-Based Compoundson Carbapenemase-Producing Acinetobacter Baumannii Clinical Strains: Efficacy Against Planktonic- And Biofilm-Growing Cells, Roberta F. Ventura, Anna Clara M. Galdino, Livia Viganor, Ricardo P. Schuenck, Michael Devereux, Malachy Mccann, André L.S. Santos, Ana Paula F. Nunes
Articles
Therapeutic options are limited for patients infected with Acinetobacter baumannii due to its multidrug-resistance profile. So, the search for new antimicrobials against this gram-negative bacterial pathogen has become a worldwide priority. The present study aimed to evaluate the effects of 1,10-phenanthroline (phen), 1,10-phenanthroline-5,6-dione (phendione), [Ag(phendione)2]ClO4 (Ag-phendione) and [Cu(phendione)3](ClO4)2.4H2O (Cu-phendione) on 26 carbapenemase-producing A. baumannii strains. The susceptibility to carbapenems was performed by detecting the metallo-beta-lactamase (MBL) genes by PCR and by determining the MIC. Also, disk diffusion method was applied to evaluate the susceptibility to other antimicrobial classes. The test compounds were evaluated on both planktonic- and biofilm-growing bacterial cells. …