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Full-Text Articles in Life Sciences
Genetic Characterization And Role In Virulence Of The Ribonucleotide Reductases Of Streptococcus Sanguinis, Delacy V. Rhodes, Katie E. Crump, Olga Makhlynets, Melanie Snyder, Xiuchun Ge, Ping Xu, Joanne Stubbe, Todd Kitten
Genetic Characterization And Role In Virulence Of The Ribonucleotide Reductases Of Streptococcus Sanguinis, Delacy V. Rhodes, Katie E. Crump, Olga Makhlynets, Melanie Snyder, Xiuchun Ge, Ping Xu, Joanne Stubbe, Todd Kitten
Biology Faculty Articles
Streptococcus sanguinis is a cause of infective endocarditis and has been shown to require a manganese transporter called SsaB for virulence and O2 tolerance. Like certain other pathogens, S. sanguinis possesses aerobic class Ib (NrdEF) and anaerobic class III (NrdDG) ribonucleotide reductases (RNRs) that perform the essential function of reducing ribonucleotides to deoxyribonucleotides. The accompanying paper (Makhlynets, O., Boal, A. K., Rhodes, D. V., Kitten, T., Rosenzweig, A. C., and Stubbe, J. (2014) J. Biol. Chem. 289, 6259–6272) indicates that in the presence of O2, the S. sanguinis class Ib RNR self-assembles an essential diferric-tyrosyl radical (Fe …