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A Survey Of Β-Lactam Antibiotic Resistance Genes And Culturable Ampicillin Resistant Bacteria In Minnesota Soils, Emily M. Wollmuth
A Survey Of Β-Lactam Antibiotic Resistance Genes And Culturable Ampicillin Resistant Bacteria In Minnesota Soils, Emily M. Wollmuth
Departmental Honors Projects
Since the discovery of penicillin, antibiotics have been an essential tool in the treatment of bacterial infections and diseases. It is estimated that antibiotics and antibiotic resistance genes have existed for billions of years. With the increasing appearance of resistant pathogenic bacteria, there has been growing concern. β-lactam antibiotics make up the largest portion of the global market, so resistance to these antibiotics is especially alarming. It has been theorized that frequency and type of antibiotic resistance genes vary by area. Previous studies suggest that these differences may be related to antibiotic use in agricultural and urban areas. To survey …
Antibiotic Resistance Genes In Minnesota Soil Bacteria From Areas Of High And Low Ferric Iron, Gunner L. Drossel, Presley Martin Phd
Antibiotic Resistance Genes In Minnesota Soil Bacteria From Areas Of High And Low Ferric Iron, Gunner L. Drossel, Presley Martin Phd
Departmental Honors Projects
Naturally-occurring antibiotic resistance genes in soil bacteria represent a potentially important reservoir of genes that could contribute to antibiotic resistance of human pathogens. It has been reported that over 40 genes in bacterial genomes are controlled by concentrations of ferric iron. We examined the effect of soil metal content on the level of resistance to two antibiotics, ampicillin (Amp) and tetracycline (Tet), and the presence of multiple genes that code for efflux pump-mediated resistance. These pumps act to export toxins (e.g. heavy metals and antibiotics, perhaps). Because of this, growth in heavy metal-contaminated soils might select for antibiotic resistance. Ninety-six …